Apratoxin A, a cyclodepsipeptide isolated from cyanobacterial Lyngbya spp, has been synthesized. The total synthesis features stereocontrolled access to the novel polyketide and...

Octa-5,7-dienylidenecyclopropanes undergo [4 + 3] intramolecular cycloaddition reactions upon treatment with appropriate palladium catalysts to give stereochemically rich...

Benzynes generated by the reaction of o-(trimethylsilyl)aryl triflates with TBAT participate in intramolecular [4 + 2] cycloadditions with conjugated enynes, arenynes, and...

The total synthesis of (+)-zoapatanol utilizing an intramolecular Horner−Wadsworth−Emmons olefination and an enantioselective Sharpless dihydroxylation as the key steps has been...

The intramolecular Pauson−Khand reaction of 2-oxazolone derivatives with a suitable pentynyl appendage exclusively gave the corresponding...

10 páginas, 5 figuiras, 5 esquemas, 2 tablas.-- Supporting Information Available: General experimental procedures, 1D (1H and 13C) and 2D NMR (DQ-COSY, NOESY, HSQC, and HMBC)...

The intramolecular Friedel−Crafts acylation of benzyl Meldrum's acids is catalyzed by Sc(OTf)3 under mild reaction conditions. Several polysubstituted 1-indanones have been...

A total synthesis of (±)-phomactin A is described to highlight the final completion of a complex natural product target that had commenced with an intramolecular oxa-[3 + 3]...

A novel approach for the preparation of symmetrical (chlorin−chlorin), and unsymmetrical (chlorin−porphyrin) dimers joined with carbon−carbon linkages as models to study the...

An intramolecular hetero-Diels-Alder cycloadduct of an acyl nitroso compound and a 9, 10-dimethyl anthracene derivative was prepared as a potential nitroxyl (HNO) donor. This...

This paper reports a series of chloride anion receptors containing two catechol head groups connected through their ortho-positions via a spacer chain. The linking group chosen...

A halogen-selective tandem intramolecular Heck/carbonylation reaction has been developed for the construction of the C,E,F-ring system and the C20 quaternary center found in...

A concise synthesis of a series of novel dibenzoxepino[4,5-d]pyrazoles was accomplished by implementation of an intramolecular Ullmann-ether reaction on...

The intramolecular Diels−Alder reaction of 5-vinyl-1,3-cyclohexadienes affording substituted tricyclo[3.2.1.02,7]oct-3-enes is studied.

The total synthesis of VM55599, a natural metabolite of Penicillium sp. IMI332995, has been achieved via an intramolecular Diels−Alder cycloaddition of a reverse isoprene moiety...

The 11α- and 11β-modified androst-5-ene derivatives 3a,b as well as the exo- and endocyclic dehydrated compounds 4a−c and 5b−c were produced using the oxalate derivatives of the...

The tetracyclic core of the diterpene bielschowskysin has been prepared as a single enantiomer via a stereoselective intramolecular [2 + 2] photocycloaddition of...

A novel and general copper/silver catalytic system has been developed for the Conia-ene intramolecular reaction of linear β-alkynic β-ketoesters. In the presence of...

Brevetoxin-B (BTX-B), produced by the red tide organism, Gymnodium breve Davis, is the first member of marine polycyclic ethers to be structurally elucidated and one of the most...

An enantioselective organocatalytic intramolecular ring-closing Friedel−Crafts-type alkylation of indolyl α,β-unsaturated aldehydes has been developed. This powerful new...