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Toward the Total Synthesis of Eurifoloid A
Construction of the [5–7–7] tricyclic core of eurifoloid A, which contains an unusual and highly strained bicyclo[4.4.1]undecane ring system with trans-bridgehead, was... -
r37980778c78--d077ff41253e4ab93f54c4ab025aa856
Construction of the [5–7–7] tricyclic core of eurifoloid A, which contains an unusual and highly strained bicyclo[4.4.1]undecane ring system with trans-bridgehead, was... -
Conjugated Thiophene-Fused Isatin Dyes through Intramolecular Direct Arylation
We report on the design, synthesis, and properties of innovative, planar, π-conjugated compounds in which a thiophene ring is fused with the skeleton of the naturally occurring... -
Copper-Mediated Oxidative Coupling of Benzamides with Maleimides via Directed...
A Cu(OAc)2/Cy2NMe-mediated oxidative direct coupling of benzamides with maleimides has been developed. The aromatic C–H alkenylation with the aid of an 8-aminoquinoline-based... -
Ortho-Substituted Catechol Derivatives: The Effect of Intramolecular Hydroge...
This paper reports a series of chloride anion receptors containing two catechol head groups connected through their ortho-positions via a spacer chain. The linking group chosen... -
Enantioselective Synthesis of Tetrahydroisoquinolines via Iridium-Catalyzed I...
An efficient iridium-catalyzed intramolecular Friedel–Crafts-type allylic alkylation reaction of phenols was developed, affording tetrahydroisoquinolines with moderate to... -
r37980778c78--0c607d82880ae7bfd57b8d788a3c8be8
To investigate diazepinone analogues as γ-turn mimics, seven 1,4-benzodiazepin-2-ones 6 and fourteen pyrrolo[1,2-d][1,4]benzodiazepin-6-ones 4 and 5 were synthesized from... -
Grignard Reagent-Mediated Conversion of an Acyl Nitroso-anthracene Cycloadduc...
An intramolecular hetero-Diels−Alder cycloadduct of an acyl nitroso compound and a 9,10-dimethyl anthracene derivative was prepared as a potential nitroxyl (HNO) donor. This... -
Total Synthesis of Phomactin A
A total synthesis of (±)-phomactin A is described to highlight the final completion of a complex natural product target that had commenced with an intramolecular oxa-[3 + 3]... -
Total Synthesis of (+)-Viridianol, a Marine-Derived Sesquiterpene Embodying t...
A total synthesis of the title sesquiterpene 4 is described that starts with the chiral, non-racemic cis-1,2-dihydrocatechol 10 obtained through the whole-cell biotransformation... -
r37980778c78--24092af999f90ed9a1547e1bedfbaa9c
To investigate diazepinone analogues as γ-turn mimics, seven 1,4-benzodiazepin-2-ones 6 and fourteen pyrrolo[1,2-d][1,4]benzodiazepin-6-ones 4 and 5 were synthesized from... -
r37980778c78--9d8e3201721bcbea0bd831abbdd27b49
Catalyzed by a triazole carbene, the dimerization of 2-formylcinnamates underwent benzoin condensation followed by intramolecular oxa-Michael addition to afford... -
Synthesis of the Tricyclic Ring Structure of Daphnanes via Intramolecular [4 ...
A synthetic approach toward the tricyclic 5,7,6-membered ring structure of daphnane-family natural products is described. An intramolecular [4 + 3] cycloaddition reaction of... -
γ‑Turn Mimicry with Benzodiazepinones and Pyrrolobenzodiazepinones Synthesize...
To investigate diazepinone analogues as γ-turn mimics, seven 1,4-benzodiazepin-2-ones 6 and fourteen pyrrolo[1,2-d][1,4]benzodiazepin-6-ones 4 and 5 were synthesized from... -
r37980778c78--94e9f8a47dc68284de7d81c6af2a087d
The synthesis and structure of a C3-symmetric propeller-shaped polycyclic aromatic hydrocarbon that bears three seven-membered rings is reported. The synthesis was accomplished... -
r37980778c78--17d10d2c48d0604a80cc722ec329c390
A highly selective intramolecular trans-silylvinylation of internal alkynes catalyzed by RuHCl(CO)(SIMes)(PPh3) has been accomplished. The use of methyl vinyl ketone as an... -
An Approach to the Total Synthesis of the Marine Ascidian Metabolite Perophor...
A halogen-selective tandem intramolecular Heck/carbonylation reaction has been developed for the construction of the C,E,F-ring system and the C20 quaternary center found in... -
Diastereoselective Intramolecular [3 + 2]-Annulation of Donor–Acceptor Cyclop...
An intramolecular [3 + 2]-annulation of amide-linked donor–acceptor cyclopropane with in situ-generated imine is described. As a result, diverse... -
r37980778c78--b313220f916759f1f4acdbd0ac133c8f
The redox-neutral direct coupling of arylphosphine oxides with heterobicyclic alkenes proceeds smoothly under rhodium(III) catalysis involving hydroarylation followed by... -
Ethylene Transposition: Ruthenium Hydride Catalyzed Intramolecular <i>trans</...
A highly selective intramolecular trans-silylvinylation of internal alkynes catalyzed by RuHCl(CO)(SIMes)(PPh3) has been accomplished. The use of methyl vinyl ketone as an...
