Background 25% of breast cancer patients suffer from aggressive HER2-positive tumours that are characterised by overexpression of the HER2 protein or by its increased tyrosine...

Background Prokaryotic 16S ribosomal RNA (rRNA) sequences are widely used in environmental microbiology and molecular evolution as reliable markers for the taxonomic...

Background: The analysis of next generation sequencing (NGS) has become a standard task for many laboratories in the life sciences. Though there exists several tools to support...

Background: During the last decade, the interest to apply machine learning algorithms to genomic data has increased in many bioinformatics applications. Analyzing this type of...

Independent component analysis (ICA) is a popular blind source separation technique used in many scientific disciplines. Current ICA approaches have focused on developing...

In the existing literature of MCMC diagnostics, we have identified two areas for improvement. Firstly, the density-based diagnostic tools currently available in the literature...

Made available in DSpace on 2018-11-26T16:16:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-04-03 EPSRC Fundação de Amparo à Pesquisa do Estado de São Paulo...

Non-normality and heteroscedasticity are common in applications. For the comparison of two samples in the non-parametric Behrens-Fisher problem, different tests have been...

Background Functional annotation of genes and gene products is a major challenge in the post-genomic era. Nowadays, gene function curation is largely based on manual assignment...

ABSTRACTThis article introduces an optimization framework for the integrated design of a planetary surface rover and its exploration route that is applicable to the initial...

In this paper, a conservative finite difference scheme to solve the generalized Rosenau-RLW equation in 2D is proposed. The proposed scheme is linear-implicit, mass-preserving,...

Background Detecting somatic mutations in whole exome sequencing data of cancer samples has become a popular approach for profiling cancer development, progression and...

In practice, engineering optimization problems come in various complexities that are different from the usual problem formulations used in a single academic study. To solve such...

Background Factor graphs provide a flexible and general framework for specifying probability distributions. They can capture a range of popular and recent models for analysis of...

Background Much effort is underway to build and upgrade databases and tools related to occurrence, diversity, and characterization of CRISPR-Cas systems. As microbial...

Background Recent studies have shown that the crosstalk between microRNA (miRNA) sponges plays an important role in human cancers. However, the co-regulation roles of miRNA...

Along with a growing body of evidence of the challenges experienced by specialist and more-able mathematics students during their undergraduate studies, there now exists...

Background Post-transcriptional regulation is a complex mechanism that plays a central role in defining multiple cellular identities starting from a common genome. Modifications...

Background It is extremely common to need to select a subset of reads from a BAM file based on their specific properties. Typically, a user unpacks the BAM file to a text stream...

Background Reconstruction of executable mechanistic models from single-cell gene expression data represents a powerful approach to understanding developmental and disease...