-
Food perception without ingestion leads to metabolic changes and irreversible...
Background Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food... -
Sensitivity and correlation of hypervariable regions in 16S rRNA genes in phy...
Background Prokaryotic 16S ribosomal RNA (rRNA) sequences are widely used in environmental microbiology and molecular evolution as reliable markers for the taxonomic... -
Emergence of wheat blast in Bangladesh was caused by a South American lineage...
Made available in DSpace on 2018-12-11T17:06:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-10-03 Background: In February 2016, a new fungal disease was spotted in... -
Central peptidergic modulation of peripheral olfactory responses
Background Animal olfactory systems detect volatile environmental chemicals and integrate this information to direct the discovery of food and mates as well as danger avoidance.... -
Inferring miRNA sponge co-regulation of protein-protein interactions in human...
Background Recent studies have shown that the crosstalk between microRNA (miRNA) sponges plays an important role in human cancers. However, the co-regulation roles of miRNA... -
Estimating cumulative pathway effects on risk for age-related macular degener...
Background Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10 % of... -
Deciphering the signaling mechanisms of the plant cell wall degradation machi...
Background The gene expression and secretion of fungal lignocellulolytic enzymes are tightly controlled at the transcription level using independent mechanisms to respond to... -
Somato-dendritic decoupling as a novel mechanism for protracted cortical matu...
Background Both human and animal data indicate that disruption of the endogenously slow maturation of temporal association cortical (TeA) networks is associated with abnormal... -
New tools to analyze overlapping coding regions
Background Retroviruses transcribe messenger RNA for the overlapping Gag and Gag-Pol polyproteins, by using a programmed -1 ribosomal frameshift which requires a slippery... -
Clonal raider ant brain transcriptomics identifies candidate molecular mechan...
Background Division of labor between reproductive queens and workers that perform brood care is a hallmark of insect societies. However, studies of the molecular basis of this... -
The wright stuff: reimagining path analysis reveals novel components of the s...
Background The Drosophila sex determination hierarchy is a classic example of a transcriptional regulatory hierarchy, with sex-specific isoforms regulating morphology and... -
Application of long single-stranded DNA donors in genome editing: generation ...
Background Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long... -
"A scalability study of phylogenetic network inference methods using empirica...
Background Branching events in phylogenetic trees reflect bifurcating and/or multifurcating speciation and splitting events. In the presence of gene flow, a phylogeny cannot be... -
A live cell assay of GPCR coupling allows identification of optogenetic tools...
Background Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in... -
The native microbiome of the nematode Caenorhabditis elegans: gateway to a ne...
Background Host-microbe associations underlie many key processes of host development, immunity, and life history. Yet, none of the current research on the central model species... -
A systematic survey of centrality measures for protein-protein interaction ne...
AbstractBackgroundNumerous centrality measures have been introduced to identify “central” nodes in large networks. The availability of a wide range of measures for ranking... -
A benchmark for microRNA quantification algorithms using the OpenArray platform
Background Several techniques have been tailored to the quantification of microRNA expression, including hybridization arrays, quantitative PCR (qPCR), and high-throughput... -
CDC42 controls the activation of primordial follicles by regulating PI3K sign...
Background In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan. Misregulated... -
A phosphoinositide map at the shoot apical meristem in Arabidopsis thaliana
Background In plants, the shoot apical meristem (SAM) has two main functions, involving the production of all aerial organs on the one hand and self-maintenance on the other,... -
Updated and standardized genome-scale reconstruction of <i>Mycobacterium tube...
Background The efficacy of antibiotics against M. tuberculosis has been shown to be influenced by experimental media conditions. Investigations of M. tuberculosis growth in...
