Central peptidergic modulation of peripheral olfactory responses

Background Animal olfactory systems detect volatile environmental chemicals and integrate this information to direct the discovery of food and mates as well as danger avoidance. Rather than remaining constant, olfactory response thresholds are modulated by internal and external cues to adapt odor-guided behaviors to changing conditions. Results Here, we show in Drosophila melanogaster that neuropeptide F (NPF) modulates the responses of a specific population of antennal olfactory sensory neurons (OSNs) to food-derived odors. We show that knock-down of NPF in NPF neurons specifically reduces the responses of the ab3A neurons to ethyl butyrate, a volatile ester found in apples and other fruits. Knock-down of the NPF receptor (NPFR) in the ab3A neuron reduces their responses and disrupts the ability of the flies to locate food. We also identify a sexual dimorphism in ab3A responsiveness: ab3A neurons in females immediately post-eclosion are less responsive to ethyl butyrate than those of both age-matched males and older females. Not only does this change correlate with brain NPF levels, but also NPFR mutants show no such sexual dimorphism. Finally, by way of mechanism, we show that mutation of NPFR seems to cause intracellular clustering of OR22a, the odorant receptor expressed in the ab3A neurons. Conclusions Interestingly, this modulation of the peripheral odorant responsiveness of the ab3A neurons by NPF is distinct from the modulation of presynaptic gain in the ab3A neurons previously observed with the similarly named but distinct neuropeptide sNPF. Rather than affecting the strength of the output at the level of the first synapse in the antennal lobe, NPF-NPFR signaling may affect the process of odorant detection itself by causing intracellular OR clustering. Electronic supplementary material The online version of this article (doi:10.1186/s12915-017-0374-6) contains supplementary material, which is available to authorized users.

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PID https://www.doi.org/10.1186/s12915-017-0374-6
PID pmc:PMC5420127
PID pmid:28476120
URL https://link.springer.com/article/10.1186/s12915-017-0374-6
URL http://link.springer.com/content/pdf/10.1186/s12915-017-0374-6.pdf
URL http://europepmc.org/articles/PMC5420127
URL https://dx.doi.org/10.1186/s12915-017-0374-6
URL https://www.ncbi.nlm.nih.gov/pubmed/28476120
URL https://doaj.org/toc/1741-7007
URL https://academic.microsoft.com/#/detail/2611738295
URL https://0-bmcbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12915-017-0374-6
URL http://link.springer.com/article/10.1186/s12915-017-0374-6
URL http://www.ncbi.nlm.nih.gov/pubmed/28476120
URL https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0374-6
URL http://dx.doi.org/10.1186/s12915-017-0374-6
URL https://bmcbiol.biomedcentral.com/track/pdf/10.1186/s12915-017-0374-6
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Access Right Open Access
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Author Young-Joon Kim, 0000-0002-7990-754X
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Collected From Europe PubMed Central; PubMed Central; ORCID; Datacite; UnpayWall; DOAJ-Articles; Crossref; Microsoft Academic Graph
Hosted By Europe PubMed Central; BMC Biology
Publication Date 2017-05-05
Publisher Springer Science and Business Media LLC
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Language UNKNOWN
Resource Type Other literature type; Article; UNKNOWN
keyword keywords.General Biochemistry, Genetics and Molecular Biology
keyword keywords.Ecology, Evolution, Behavior and Systematics
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::88fcc8777edfa9750b05b0b7117dac00
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Last Updated 26 December 2020, 16:46 (CET)
Created 26 December 2020, 16:46 (CET)