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Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organi...
Abstract Background Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1... -
dedup_wf_001--678de25d4a66913eeaf6f1bd36b33ffe
Additional file 1. Representative standard curve and amplification plot from each let-7 family member RT-qPCR. Standard curve and amplification plot from (A) let-7a, (B) let-7b,... -
Figure 4
Nematodes were reared on the indicated bacterium until three days old, then were either left at standard conditions or heat shocked. To quantify offspring, we washed worms off... -
Aging
Data documenting post-capture survival in days for wild flies caught across seasonal time and full lifespan of their F1 offspring. -
Additional file 6: Figure S5. of Development of an integrated approach for co...
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) (A), interleukin (IL)-1α (B), IL-1β (C), IL-5 (D), IL-10 (E), Keratinocyte-derived Chemokine (KC) (F), Macrophage... -
Pirfenidone attenuates lung fibrotic fibroblast responses to transforming gro...
Abstract Background Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation,... -
Visualization of activity-regulated BDNF expression in the living mouse brain...
Abstract Altered levels of brain-derived neurotrophic factor (BDNF) have been reported in neurologically diseased human brains. Therefore, it is important to understand how the... -
The Red Queen in the Repository: metadata quality in an ever-changing environ...
This fileset contains a preprint version of the conference paper (.pdf), presentation slides (as .pptx) and the dataset(s) and validation schema(s) for the IDCC 2019 (Melbourne)... -
Study dataset.
Compliance with NPG checklist items: data dictionary available in project space. In version 2, 7 errors from the previous version at database lock (publication date for PMID... -
Leptin receptor signaling is required for high-fat diet-induced atrophic gast...
Abstract Background Obesity increases the risk for malignancies in various tissues including the stomach. Atrophic gastritis with precancerous lesions is an obesity-associated... -
TRPV1 mediates astrocyte activation and interleukin-1β release induced by hyp...
Abstract Background Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with high incidence in both advanced and developing countries. Children surviving from... -
Additional file 2 of Metabolic characterization of aggressive breast cancer c...
Additional file 2: Supplemental Figure 2. Mitochondrial membrane potential of SUM149 invading cells. -
Additional file 1 of Impact of malnutrition on systemic immune and metabolic ...
Additional file 1: Figure S1. Flowchart for the study participant recruitment. A flowchart illustrating participant recruitment to the study. -
Test set for geodesics
This is a set of 500000 geodesics for the WGS84 ellipsoid; this is an ellipsoid of revolution with equatorial radius a = 6378137 m and flattening f = 1/298.257223563. Each... -
Increased circulating microRNA-122 is associated with mortality and acute liv...
Abstract Background Acute liver injury in patients with ARDS decreases survival but early stages may be easily missed due to the lack of sufficient biomarkers signalling its... -
Additional file 3: of Understanding the regulatory mechanisms of milk product...
Table S4. Differentially expressed genes in the mammary gland of cows fed corn stover (CS) vs. alfalfa hay (AH). The cutoff is set at 1.5-fold change and p < 0.05. Table S5.... -
The human fetal adrenal produces cortisol but no detectable aldosterone throu...
Abstract Background Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth... -
Circulating microRNA-92a level predicts acute coronary syndrome in diabetic p...
Abstract Purpose This study was designed to explore the value of monitoring miR-92a in T2DM patients with coronary heart disease (CHD). Materials and methods 40 ACS patients... -
Single nucleotide polymorphisms in apoptosis pathway are associated with resp...
Abstract Background The mechanism of action of imatinib is known to involve the Fas-mediated apoptosis pathway. Consequently inter-individual variations in this apoptosis... -
Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, ne...
Abstract Background Glutamate-induced excitotoxicity, oxidative damage, and neuroinflammation are believed to play an important role in the development of a number of CNS...
