Algorithm and software to automatically identify latency and amplitude features of local field potentials recorded in electrophysiological investigation

Background Local field potentials (LFPs) evoked by sensory stimulation are particularly useful in electrophysiological research. For instance, spike timing and current transmembrane current flow estimated from LFPs recorded in the barrel cortex in rats and mice are exploited to investigate how the brain represents sensory stimuli. Recent improvements in microelectrodes technology enable neuroscientists to acquire a great amount of LFPs during the same experimental session, calling for algorithms for their quantitative automatic analysis. Several computer tools were proposed for LFP analysis, but many of them incorporate algorithms that are not open to inspection or modification/personalization. We present a MATLAB software to automatically detect some important LFP features (latency, amplitude, time-derivative value in the inflection-point) for a quantitative analysis. The software features can be customized by the user according to his/her personal research needs. The incorporated algorithm is based on Phillips-Tikhonov regularization to deal with noise amplification due to ill-conditioning. In particular, its accuracy in the estimation of the features of interest is assessed in a Monte Carlo simulation mimicking the acquisition of LFPs in different SNR (signal-to-noise-ratio) conditions. Then, the algorithm is tested by analyzing a real set of 2500 LFPs recorded in rat after whisker stimulation at different depths in the primary somatosensory (S1) cortex, i.e., the region involved in the cortical representation of touch in mammals. Results Automatic identification of LFP features by the presented software is easy and fast. As far as accuracy is concerned, error indices from simulated data suggest that the algorithm provides reliable estimates . Indeed, results obtained from LFPs recorded in rat after whisker stimulation are in line with the known sequential activation of the microcircuits of the S1 cortex. Conclusion A MATLAB software implementing an algorithm to automatically detect the main LFPs features was presented. Simulated and real case studies showed that the employed algorithm is accurate and robust against measurement noise. The available code can be used as it is, but the reported description of the algorithms allows users to easily modify the code to cope with specific requirements. Electronic supplementary material The online version of this article (doi:10.1186/s13029-017-0062-5) contains supplementary material, which is available to authorized users.

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PID https://www.doi.org/10.1186/s13029-017-0062-5
PID pmc:PMC5297145
PID pmid:28191033
URL http://hdl.handle.net/11577/3227555
URL https://academic.microsoft.com/#/detail/2587728856
URL https://scfbm.biomedcentral.com/track/pdf/10.1186/s13029-017-0062-5?site=scfbm.biomedcentral.com
URL http://europepmc.org/articles/PMC5297145
URL https://scfbm.biomedcentral.com/track/pdf/10.1186/s13029-017-0062-5
URL https://scfbm.biomedcentral.com/articles/10.1186/s13029-017-0062-5
URL http://dx.doi.org/10.1186/s13029-017-0062-5
URL https://link.springer.com/article/10.1186/s13029-017-0062-5
URL https://www.ncbi.nlm.nih.gov/pubmed/28191033
URL https://dblp.uni-trier.de/db/journals/scfbm/scfbm12.html#RubegaCVS17
URL https://core.ac.uk/display/81823417
URL http://link.springer.com/content/pdf/10.1186/s13029-017-0062-5.pdf
URL https://dx.doi.org/10.1186/s13029-017-0062-5
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Access Right Open Access
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Author Maria Rubega, 0000-0002-0744-3109
Author STEFANO VASSANELLI, 0000-0003-0389-8023
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Collected From Europe PubMed Central; PubMed Central; ORCID; UnpayWall; Datacite; Crossref; Archivio istituzionale della ricerca - Università di Padova; Microsoft Academic Graph; CORE (RIOXX-UK Aggregator)
Hosted By Europe PubMed Central; SpringerOpen; Source Code for Biology and Medicine; Archivio istituzionale della ricerca - Università di Padova
Journal Source Code for Biology and Medicine, 12,
Publication Date 2017-02-01
Publisher BioMed Central
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Country Italy
Language English
Resource Type Article; UNKNOWN
keyword Automated analysis; LFP; Neuroscience; Phillips-Tikhonov regularization; Rat barrel cortex; Whisker stimulation; Information Systems; Computer Science Applications1707 Computer Vision and Pattern Recognition; Health Informatics; Information Systems and Management
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::5fc41f5c9d6d905ed3523a04b1ba9132
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Last Updated 26 December 2020, 20:55 (CET)
Created 26 December 2020, 20:55 (CET)