Low-cost feedback-controlled syringe pressure pumps for microfluidics applications.

Microfluidics are widely used in research ranging from bioengineering and biomedical disciplines to chemistry and nanotechnology. As such, there are a large number of options for the devices used to drive and control flow through microfluidic channels. Commercially available syringe pumps are probably the most commonly used instruments for this purpose, but are relatively high-cost and have inherent limitations due to their flow profiles when they are run open-loop. Here, we present a low-cost ($110) syringe pressure pump that uses feedback control to regulate the pressure into microfluidic chips. Using an open-source microcontroller board (Arduino), we demonstrate an easily operated and programmable syringe pump that can be run using either a PID or bang-bang control method. Through feedback control of the pressure at the inlets of two microfluidic geometries, we have shown stability of our device to within ±1% of the set point using a PID control method and within ±5% of the set point using a bang-bang control method with response times of less than 1 second. This device offers a low-cost option to drive and control well-regulated pressure-driven flow through microfluidic chips.

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PID pmid:28369134
PID https://www.doi.org/10.1371/journal.pone.0175089
PID pmc:PMC5378403
URL https://www.ncbi.nlm.nih.gov/pubmed/28369134
URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175089
URL http://dx.plos.org/10.1371/journal.pone.0175089
URL https://dx.doi.org/10.1371/journal.pone.0175089
URL https://paperity.org/p/80303037/low-cost-feedback-controlled-syringe-pressure-pumps-for-microfluidics-applications
URL http://dx.doi.org/10.1371/journal.pone.0175089
URL https://core.ac.uk/display/149564579
URL http://europepmc.org/articles/PMC5378403
URL https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175089&type=printable
URL https://academic.microsoft.com/#/detail/2605000130
URL https://doaj.org/toc/1932-6203
URL https://dx.plos.org/10.1371/journal.pone.0175089
URL http://europepmc.org/articles/PMC5378403?pdf=render
URL http://ui.adsabs.harvard.edu/abs/2017PLoSO..1275089L/abstract
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Access Right Open Access
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Author John R. Lake, 0000-0002-7610-1559
Author Keith C. Heyde
Author Warren C. Ruder, 0000-0003-0745-9933
Contributor Wanunu, Meni
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Collected From Europe PubMed Central; PubMed Central; ORCID; Datacite; UnpayWall; DOAJ-Articles; Crossref; Microsoft Academic Graph
Hosted By Europe PubMed Central; PLoS ONE
Publication Date 2017-04-03
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keyword Q
keyword R
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::23e5d6d44a5fa8448337b08952c86e19
Author jsonws_user
Last Updated 23 December 2020, 13:12 (CET)
Created 23 December 2020, 13:12 (CET)