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The diagnostic accuracy of the hand-held Raman spectrometer for the identific...
Abstract Background There is a need for accurate and field-applicable instruments for the evaluation of the quality of anti-malarial drugs. The aim of this study was to... -
Homozygous TBC1 domain-containing kinase (TBCK) mutation causes a novel lysos...
Abstract Homozygous mutation of TBC1 domain-containing kinase (TBCK) is the cause of a very recently defined severe childhood disorder, which is characterized by severe... -
Ancient coexistence of norepinephrine, tyramine, and octopamine signaling in ...
Abstract Background Norepinephrine/noradrenaline is a neurotransmitter implicated in arousal and other aspects of vertebrate behavior and physiology. In invertebrates,... -
Infection prevention and control measures and tools for the prevention of ent...
Abstract Background Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with... -
Nosological delineation of congenital ocular motor apraxia type Cogan: an obs...
Abstract Background The nosological assignment of congenital ocular motor apraxia type Cogan (COMA) is still controversial. While regarded as a distinct entity by some... -
Longitudinal estimation of Plasmodium falciparum prevalence in relation to ma...
Abstract Background Plasmodium falciparum prevalence (PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with... -
Maternal eNOS Deficiency Determines a Fatty Liver Phenotype of the Offspring ...
Maternal environmental factors can impact the phenotype of the offspring via the induction of epigenetic adaptive mechanisms. The advanced fetal programming hypothesis proposes... -
SRF modulates seizure occurrence, activity induced gene transcription and hip...
Abstract A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE... -
Inflammatory profile in LRRK2-associated prodromal and clinical PD
Abstract Background There is evidence for a relevant role of inflammation in the pathogenesis of Parkinsonâ s disease (PD). Mutations in the LRRK2 gene represent the most... -
Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation o...
Abstract To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of >6 million single nucleotide... -
A systematic review of the clinical presentation, treatment and relapse chara...
Abstract Background Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or... -
Safety and efficacy of the choline analogue SAR97276 for malaria treatment: r...
Abstract Background Malaria remains one of the most important infectious diseases. Treatment options for severe malaria are limited and the choline analogue SAR97276A is a novel... -
Current progress and future opportunities in applications of bioinformatics f...
Abstract The Mid-Atlantic Microbiome Meet-up (M3) organization brings together academic, government, and industry groups to share ideas and develop best practices for microbiome... -
Microdeletions in 9q33.3-q34.11 in five patients with intellectual disability...
Abstract Background Most microdeletions involving chromosome sub-bands 9q33.3-9q34.11 to this point have been detected by analyses focused on STXBP1, a gene known to cause early...
