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Characterization of the regulation mechanism of grapevine microRNA172 family ...
Abstract Background Grapevine (Vitis vinifera L.), which has important nutritional values and health benefits, is one of the most economically important fruit crops cultivated... -
Impaired type I interferon regulation in the blood transcriptome of recurrent...
Abstract Background Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and... -
Polymorphisms of HOMER1 gene are associated with piglet splay leg syndrome an...
Abstract Background In our previous genome-wide association study (GWAS) on the piglet splay leg (PSL) syndrome, the homer scaffolding protein 1 (HOMER1) was detected as a... -
Systematic discovery of novel eukaryotic transcriptional regulators using seq...
Abstract Background The molecular function of a gene is most commonly inferred by sequence similarity. Therefore, genes that lack sufficient sequence similarity to characterized... -
De novo transcriptome sequencing of radish (Raphanus sativus L.) fleshy roots...
Abstract Background The HongXin radish (Raphanus sativus L.), which contains the natural red pigment (red radish pigment), is grown in the Fuling district of Chongqing City.... -
Wnt signal transduction pathways: modules, development and evolution
Abstract Background Wnt signal transduction pathway (Wnt STP) is a crucial intracellular pathway mainly due to its participation in important biological processes, functions,... -
Expression of an endoglucanase–cellobiohydrolase fusion protein in Saccharomy...
Abstract The low secretion levels of cellobiohydrolase I (CBHI) in yeasts are one of the key barriers preventing yeast from directly degrading and utilizing lignocellulose. To... -
A bacterial negative transcription regulator binding on an inverted repeat in...
Abstract Background Microbial secondary metabolism is regulated by a complex and mostly-unknown network of global and pathway-specific regulators. A dozen biosynthetic gene... -
Orthologous promoters from related methylotrophic yeasts surpass expression o...
Abstract Methylotrophic yeasts such as Komagataella phaffii (syn. Pichia pastoris, Pp), Hansenula polymorpha (Hp), Candida boidinii (Cb) and Pichia methanolica (Pm) are widely... -
Protein-based biorefining driven by nitrogen-responsive transcriptional machi...
Abstract Background Protein-based bioconversion has been demonstrated as a sustainable approach to produce higher alcohols and ammonia fertilizers. However, owing to the... -
Additional file 4: of lncRNA profile of Apis mellifera and its possible role ...
Common differentially expressed lncRNAs and mRNAs among the three comparisons. (XLS 134 kb) -
Characterization and expression profiling of serine protease inhibitors in th...
Abstract Background Serine protease inhibitors (SPIs) have been found in all living organisms and play significant roles in digestion, development and innate immunity. In this... -
Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic act...
Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative... -
Suppression of peripheral NGF attenuates neuropathic pain induced by chronic ...
Abstract Background Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have been reported to significantly attenuate pain, but the mechanism involved has not... -
Having concomitant asthma phenotypes is common and independently relates to p...
Abstract Background Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In... -
Cryptic sequence features in the active postmortem transcriptome
Abstract Background Our previous study found that more than 500 transcripts significantly increased in abundance in the zebrafish and mouse several hours to days postmortem... -
Assignment of sigma factors of RNA polymerase to promoters in Corynebacterium...
Abstract Corynebacterium glutamicum is an important industrial producer of various amino acids and other metabolites. The C. glutamicum genome encodes seven sigma subunits... -
Two promoters in the esx-3 gene cluster of Mycobacterium smegmatis respond in...
Abstract Background The ESX secretion system, also known as the Type VII secretion system, is mostly found in mycobacteria and plays important roles in nutrient acquisition and... -
Age-specific incidence of allergic and non-allergic asthma
Abstract Background Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in... -
Roles of alternative splicing in modulating transcriptional regulation
Abstract Background The ability of a transcription factor to regulate its targets is modulated by a variety of genetic and epigenetic mechanisms. Alternative splicing can...
