Observed outcomes by treatment arm and by the ACCORD-BP trial population’s predicted benefit/harm (validation cohort).

Observed outcomes by treatment arm and by benefit/harm subgroup for the SPRINT trial (derivation cohort) and ACCORD-BP trial (validation cohort) when applying models fit by...

Baseline characteristics of the SPRINT trial participants included for model derivation (N = 9,069) and ACCORD-BP trial participants included for model validation (N = 4,498).

Comparison of discrimination and calibration for models fit by elastic net regularization versus traditional backwards selection.

Risk score for harm from intensive blood pressure treatment, developed from the SPRINT trial.

Risk score for benefit from intensive blood pressure treatment, developed from the SPRINT trial.

Observed outcomes by treatment arm and by the SPRINT trial population’s predicted benefit/harm (derivation cohort).

BackgroundIntensive blood pressure (BP) treatment can avert cardiovascular disease (CVD) events but can cause some serious adverse events. We sought to develop and validate risk...