All possible peptoid−peptide hybrids of an MC4 receptor agonist were synthesized and investigated on cells expressing different melanocortin (MC) receptor subtypes and for rat...

Pharmacophore/receptor models for three recombinant GABAA/BzR subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) have been established via an SAR ligand-mapping approach. This study was...

Among the heterocyclic structures identified as potent human A3 (hA3) adenosine receptor’s antagonists, we have demonstrated that the new pyrazolo-triazolo-pyrimidines, bearing...

To further investigate new potent and selective human A1 adenosine receptor agonists, we have synthesized a series of 5′-chloro-5′-deoxy- and...

Moderately potent, selective S1P1 receptor agonists identified from high-throughput screening have been adapted into lipophilic tails for a class of orally bioavailable amino...