Human PAC were exposed to nicotine (0.5 μM, 48 h) and carrier-mediated uptake of 3H-thiamin was determined as described under “Materials and Methods”. Data represents the mean ±...

Primers used to generate in situ hybridization probes.

Nicotine evokes chorda tympani (CT) taste nerve responses and an aversive behavior in Trpm5 knockout (KO) mice. The agonists and antagonists of nicotinic acetylcholine receptors...

This Excel file includes all the data used to generate the figures in the associated manuscript. The first Tab in the spreadsheet is an Index Tab with information about which...

Characteristics of study population (n = 285).

i = TRPM5-dependent (t) or TRPM5-independent component (a) ri = CT response to receptor class i at nicotine concentration, c bi = maximum response of the receptor class i ki...

Unadjusted and multivariable associations between self-reported TSE, measurable saliva cotinine, and airborne apartment nicotine.

Contains the following files: Figure S1. Complete serum free medium does not contain nerve growth factor (NGF). NGF levels in complete serum free medium were measured by ELISA...

a Based on smoking 1 pack/day.b Based on respiration rate of 30 breaths/minute and tidal volume of 60 ml in a room with 30 µg/m3 nicotine and 53 ng/m3 of TSNA.c Based on 1 hour...

Chemicals identified in aqueous THS extracts.

Primary PAC were isolated from mice exposed to nicotine and their controls. Carrier -mediated [3H] thiamin uptake was determined as described in “Materials and Methods”. Data...

Distribution of saliva cotinine and apartment nicotine levels by self-reported TSE.

This movie shows changes in [Ca2+]i after microejection of ATP in flat sheet mouse stomach preparations containing the muscle layers and the myenteric plexus. Green flashes...

The activities of the promoters were determined as described in “Materials and Methods” and are presented in percentage relative to their controls. Data are mean ± SE of at...

Western blot analysis was carried out using pancreatic acinar whole cell proteins (60 μg) isolated from chronic nicotine exposed mice and their controls. Real-time PCR was...

Values are mean ± standard deviation. In demographics, M stands for males, and F, for females. Demographics of participants and radioligand information of placebo and active...

Primers used for amplifying coding region of the respective genes by quantitative PCR.

The effects of long-term use of nicotine per se on cancer risk, in the absence of tobacco extract or smoke, are not clearly understood. This review evaluates the strength of...

Neonatal mice exposed to 1.8% nicotine/PG containing E-cigarette emissions for nine consecutive days in trial one had significantly higher levels of plasma and urine cotinine...

The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for metabolism...