Background 25% of breast cancer patients suffer from aggressive HER2-positive tumours that are characterised by overexpression of the HER2 protein or by its increased tyrosine...

This study compares alternative ways of disentangling the effects of level (the tendency for a person to be high, medium, or low across all factors) and shape (the tendency for...

Aedes aegypti is an important vector of arboviruses such as dengue, yellow fever, chikungunya and Zika. Among the various types of insecticides used to combat this vector, the...

Factorial experiments, wherein two or more factors each at two or more levels are used simultaneously, have profound applications in many fields of agricultural and allied...

Being a scientist entails a common set of characteristics. Admiring nature and having concern for social issues; possessing a strong academic background, team work abilities,...

Background: During the last decade, the interest to apply machine learning algorithms to genomic data has increased in many bioinformatics applications. Analyzing this type of...

Independent component analysis (ICA) is a popular blind source separation technique used in many scientific disciplines. Current ICA approaches have focused on developing...

In this study, we propose a new open-source simulation platform that comprises computer-aided design and computer-aided engineering tools for highly automated evaluation of...

This simulation study assesses the statistical performance of two mathematically equivalent parameterizations for multitrait–multimethod data with interchangeable raters—a...

This editorial can be considered the preface to the “Ten Simple Rules” series [1–7]. The rules presented here are somewhat philosophical and behavioural rather than concrete...

In the existing literature of MCMC diagnostics, we have identified two areas for improvement. Firstly, the density-based diagnostic tools currently available in the literature...

Several structural equation modeling (SEM) strategies were developed for assessing measurement invariance (MI) across groups relaxing the assumptions of strict MI to partial,...

Made available in DSpace on 2018-11-26T16:16:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-04-03 EPSRC Fundação de Amparo à Pesquisa do Estado de São Paulo...

Non-normality and heteroscedasticity are common in applications. For the comparison of two samples in the non-parametric Behrens-Fisher problem, different tests have been...

The scale and intensity of the coronavirus disease 2019 (COVID-19) worldwide pandemic is unprecedented in all our lifetimes This is written for all of us involved in scientific...

While women are generally underrepresented in STEM fields, there are noticeable differences between fields. For instance, the gender ratio in biology is more balanced than in...

This article aims to introduce the nature of data integration to life scientists. Generally, the subject of data integration is not discussed outside the field of computational...

An important goal in researching the biology of olfaction is to link the perception of smells to the chemistry of odorants. In other words, why do some odorants smell like...

Tuning a complex simulation code refers to the process of improving the agreement of a code calculation with respect to a set of experimental data by adjusting parameters...