The top 20 drugs by the number of repurposing opportunities identified by PathFX.

DS2 consists of a downloadable zip file containing a data file; data file metadata in the form of a data column LUT; experimental metadata including a detailed protocol and...

The terms ‘Jung CUI’ and ‘Jung Disease’ are terms extracted from [36] and represent the associations between drugs and diseases found the electronic health record.

In the dense dataset, the drug-gene pairs and dependency paths represented must have occurred at least five times in Medline. In the sparse dataset, the dependency paths must...

The first line of each row shows the dependency path, the second an example of what that path would look like in the raw text. The symbol D represents the drug and G represents...

The drug and gene names flanking each path are bolded. Some key abbreviations are listed here: appos: appositional modifier, amod: adjectival modifier, prep: prepositional...

*** indicates that the drug has been shown experimentally to have modified the activity of the gene/protein ** means that the interaction is known to DrugBank but is listed...

*** indicates that an association has been demonstrated experimentally between changes in the expression/activity of the gene/protein and the efficacy of the drug ** indicates...

DS3 consists of a downloadable zip file containing a data file; data file metadata in the form of a data column LUT; experimental metadata including a detailed protocol and...

Supplemental code, model, data and results to Fröhlich, et al., Cell Systems, 2018, https://doi.org/10.1016/j.cels.2018.10.013. The contained codes are also available at...

In disease lists, ‘|’ is a delimiter to separate disease names. In drug lists, if a drug is listed multiple times, these listings reflect that the drug is intended to treat...

PathFX identifications supported by on-going clinical trials.

The published biomedical research literature encompasses most of our understanding of how drugs interact with gene products to produce physiological responses (phenotypes)....

BackgroundAttention-Deficit/Hyperactivity Disorder (ADHD) is a common psychiatric disorder in children and adolescents. Immediate-release methylphenidate (IR-MPH) is the medical...

IR-MPH = Immediate-release methylphenidate MPH-OROS = Methylphenidate osmotic release oral system QALY = Quality adjusted life years Markov model results of base case...