The expression direction (Up or Down) of thymidine analogue DEGs, with an adjusted P-value <0.01, at 72h, are compared to respectively Up or Down regulated genes from the...

Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been...

Relative quantities (%) of mtDNA compared to control animals. Numbers between parentheses indicate 95% confidence intervals (51df) from ≥3 replicates per 2 individual...

Fitness was measured by the number of sigmoidal body bends per worm per minute. FLT concentration = 200μM. Anti-oxidant concentration = 100μM. Statistics were calculated with a...

Relative body length was measured after 48hrs NRTI exposure of L1 and 96h exposure of L4 animals (30 worms in ≥2 individual experiments). NRTI concentration = 200μM. Statistics...

NRTI concentration = 200μM. Statistics were calculated by a two way ANOVA with Dunnett’s multiple comparisons test, compared to the control of that same time point, of 10 worms...

All animals are N2 exposed from L4 at 20°C. Statistics were conducted compared to the DMSO control. FLT concentration = 200μM, NAC concentration = 100μM.

The expression direction (Up or Down) of thymidine analogue DEGs, with an adjusted P-value <0.01, at 24h, are compared to respectively Up or Down regulated genes from the...