BackgroundMicrobubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical...

Inclusion and exclusion criteria used to select studies.

Summary of the type of microbubbles used including their dosage, administration route, protocols of injection by type of microbubbles (MBs/TMBs), and combination with...

Quality assessment of the studies using the collaborative approach to meta-analysis and review of Animal Data from Experimental Studies (CAMARADES) checklist items.

General description of studies that fulfilled the inclusion/exclusion criteria.

Summary of compositions of various clots, clotting time before injection, and time between injection and the start of treatment.

Conditions undergoing testing and main outcomes (p < 0.05) of the 16 studies.

Summary of the US parameters utilized in the different studies.