aCase Fatality - Estimates for stages III and IV are from Groot et al. [7] and for stages I and II from Zelle et al. [22]. The CFs for the untreated patients are from Groot et...

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aBased on estimates by Costa Rican CCSS.bUnit costs WHO-CHOICE database in 2000 US$. Corrected for inflation: 2000–2009 (2.81 in CR & 1.66 in MX). 2009 exchange rates were...

Cooperative Patent Classification (CPC) analysis.

Adherence to medications is an important indicator of the quality of medication management and impacts on health outcomes and cost-effectiveness of healthcare delivery....

Background Tramadol, a 4-phenyl-piperidine analog of codeine, has a unique action in that it has a central opioidergic, noradrenergic, serotonergic analgesic, and peripheral...

Objective To assess state coverage and utilization of Medicaid smoking cessation medication benefits among fee-for-service enrollees who smoked cigarettes. Methods We...

International audience; BACKGROUND:The European Medicines Agency (EMA) and national regulators share the responsibility to communicate to healthcare providers postmarketing...

BACKGROUND: Pulmonary embolism (PE) is correlated with increased mortality among patients with lung cancer (LC). The characteristics of patients with LC presenting with PE have...

Biomarkers can be used to enrich a clinical trial for patients at higher risk for an outcome, a strategy termed "prognostic enrichment." Methodology is needed to evaluate...

Precision medicine is a rapidly growing area of modern medical science and open source machine-learning codes promise to be a critical component for the successful development...

Background Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment for depression that is increasingly implemented in healthcare systems across the...

While the epidemiologic burden of mental health disorders in the United States has been well described over the past decade, we know relatively little about trends in how these...

Purpose Neoadjuvant chemotherapy (NCT) is typically the initial treatment for non-early breast cancer patients. We thereby conducted a meta-analysis to explore whether...

Introduction Information on benefits and risks of drugs is a key element affecting doctors’ prescribing decisions. Outreach visits promoting independent information have proved...

Background Medicines regulatory harmonization has been recommended as one way to improve access to quality-assured medicines in low- and middle-income countries. The rationale...

This work examines translational science in cancer based on theories of innovation that posit a relationship between the maturation of technologies and their capacity to...

International audience; • Regulatory approval of new tuberculosis (TB) drugs can be based on data from trial(s) using a surrogate endpoint of treatment efficacy under an...

There are inconsistent results regarding the efficacy and safety of intermittent epidural bolus (IPB) versus continuous epidural infusions (CPI) for labor analgesia. This study...