Primer sequences used in the study, NCBI reference sequences, and amplicon sizes (base pairs).

Genes differentially expressed in Cyp2b9/10/13-null female mice compared to WT female mice following microarray analysis.

Compensatory changes in CYP gene expression in Cyp3a-null mice.

We report here a novel series of benzimidazole sulfonamides that act as antagonists of the S1P1 receptor, identified by exploiting an understanding of the pharmacophore of a...

Compensatory changes in CYP gene expression in CAR-null mice.

Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from...

Biochemical parameters of liver function in healthy and cholestatic rats.

The biochemical variations induced in human primary hepatocyte cultures by reference activators of xenoreceptor CAR (NR1I3) and PXR (NR1I2), i.e., rifampicin, phenobarbital, and...

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in the regulation of multiple cellular pathways, such as xenobiotic metabolism and Th17...

Glucocorticoids (GCs) are currently used for the therapeutic management of cholestatic diseases, but their use and molecular mechanism remain controversial. The aims of this...