Background Qualitative dynamics semantics provide a coarse-grain modeling of networks dynamics by abstracting away kinetic parameters. They allow to capture general features of...

In this paper, we develop an analysis of the spatial distribution of knowledge production related to Key Emerging Technologies (KETs) and Societal Grand Challenges (SGCs) in...

Adipogenesis is the process of cell differentiation by which mesenchymal stem cells become adipocytes. Extensive research is ongoing to identify genes, their protein products,...

In this article, we present an approach for comprehensive analysis of the effectiveness of interventions based on nonlinear structural equation mixture models (NSEMM). We...

Background Dissecting the regulatory relationships between genes is a critical step towards building accurate predictive models of biological systems. A powerful approach...

Background Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition...

Background The size and complexity of published biochemical network reconstructions are steadily increasing, expanding the potential scale of derived computational models....

Background The high degree of heterogeneity observed in breast cancers makes it very difficult to classify the cancer patients into distinct clinical subgroups and consequently...

Background Networks provide effective models to study complex biological systems, such as gene and protein interaction networks. With the advent of new sequencing technologies,...

Disease similarity study provides new insights into disease taxonomy, pathogenesis, which plays a guiding role in diagnosis and treatment. The early studies were limited to...

Background Canonical correlation analysis (CCA) is a multivariate statistical method which describes the associations between two sets of variables. The objective is to find...

Twitter is one of the most popular social media platforms, with over 320 million active users as of February 2019. Twitter users can enjoy free content delivered by other users...

Abstract This study estimates the development of hybrid open access (OA), i.e. articles published openly on the web within subscription-access journals. Included in the study...

Background MicroRNAs (miRNAs) are involved in many biological processes by regulating post-transcriptional gene expression. The alterations of the regulatory pathways can cause...

Abstract Advancing our understanding of human behavior hinges on the ability of theories to unveil the mechanisms underlying such behaviors. Measuring the ability of theories...