-
Active Center Control of Termination by RNA Polymerase III and tRNA Gene Tran...
The ability of RNA polymerase (RNAP) III to efficiently recycle from termination to reinitiation is critical for abundant tRNA production during cellular proliferation,... -
<i>tcf7l2</i>, <i>mllt10/af10</i>, and <i>dot1l</i> are essential for Wnt tar...
(A–H) Representative image of BrdU incorporation into epithelial cells in the intestinal bulb of 124 hpf zebrafish embryos. BrdU staining in wild-type embryos (A) and embryos... -
Transcriptional trends for genes encoding glycolytic enzymes.
Orange indicates higher transcriptional abundance at the declining phase relative to log phase; and blue indicates the opposite trend. Significant differential transcription is... -
MLLT10/AF10 targets DOT1L-H3K79 methylation to Wnt target genes and is essent...
(A) Expression levels of MLLT10/AF10, β-catenin, DOT1L, and Tubulin analyzed by Western blotting after siRNA depletion of MLLT10/AF10. ChIP experiments in Ls174T CRCs containing... -
Specific enrichment of Mllt10/Af10 and Dot1l, and H3K79 methylation at <i>Axi...
(A) Schematic representation of the mouse Axin2 locus and amplicons scanned in Chromatin immunoprecipitation experiments by qPCR. Purified crypt and villus fractions from mouse... -
r37980778c78--070a1745442bb34c98d73b636828e79b
Depletion of mllt10/af10 and dot1l rescues expression of i-fabp in apcmcr/mcr mutant embryos, placing these genes downstream of Apc as Wnt target gene activators (A–N).... -
r37980778c78--91b0c9bab190735a96867effb0c179d3
Giardia duodenalis is the most common gastrointestinal protozoan parasite of humans and a significant contributor to the global burden of both diarrheal disease and... -
Trophozoite growth profile and differential gene transcription.
A: Average density of attached Giardia duodenalis trophozoites during in vitro growth. Error bars represent ± 1 SEM. B: Heat map displaying transcriptional abundance of all... -
Mobile-phone radiation-induced perturbation of gene-expression profiling, red...
Background: The daily use by people of wireless communication devices has increased exponentially in the last decade, begetting concerns regarding its potential health hazards.... -
r37980778c78--5e6dbe12ea9c8424763a42fd3ded8ce0
(A) Loss of MLLT10/AF10 abrogates TCF/LEF driven transcriptional activation. siRNA mediated depletion of MLLT10/AF10 reduces β-catenin/TCF driven transcription in Ls174T CRCs.... -
Primer sequences used in this study.
IL-6: interleukin-6; ICAM-1: intercellular adhesion molecule-1; TNF-α: tumor necrosis factor-alpha; TGFβ1: transforming growth factor-beta 1; collagen I/III: collagen types... -
Transcriptional profiles for the antioxidant system and surface proteins duri...
A: Transcriptional abundance for currently annotated antioxidant genes, and average (note the log scale). Gene accession numbers (GL50803) are displayed after the gene... -
Data collection and refinement statistics.
1Statistics for data from the highest-resolution shell are shown in parentheses. 2 R sym =(ΣΣ|Ihkl−〈I〉|)/(ΣIhkl), where the average intensity <I> is taken... -
r37980778c78--f1b8fef03034c81d7c00289139a24aea
Cell lysates from Ls174T CRCs were immunoprecipitated with antibodies against endogenous MLLT10/AF10 (A) and DOT1L (B) complexes and analyzed by Western blotting with the... -
Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic Replication
Upon viral infection, the mitochondrial antiviral signaling (MAVS)-IKKβ pathway is activated to restrict viral replication. Manipulation of immune signaling events by pathogens... -
Plasmids used in this study.
aLike YCpHA-BUD8 [20] except in a YEplac111 [53] background.bLike YEpGFP*-BUD8 [20] except with two in-frame copies of the GFP coding sequence and in a YCplac33 [53] background. -
Transcription of highly repetitive tandemly organized DNA in amphibians and b...
Tandemly organized highly repetitive DNA sequences are crucial structural and functional elements of eukaryotic genomes. Despite extensive evidence, satellite DNA remains an... -
A putative two-component-like signaling pathway in <i>Giardia duodenalis</i>.
A generalized complete two-component signaling pathway cartoon is displayed in grey. Putative structures for hypothetical G. duodenalis proteins are displayed in blue, with...
