Additional file 3. List of un-retrievable articles.

Additional file 2. List of peer-reviewed and grey literature sources searched.

Primer sequence information for RT-qPCR amplification. (XLSX 11 kb)

Additional file 7. ROSES Reporting Form.

Table S1. List of putative off-target sites. The top 7 potential off-target sites (OTS1-OTS7) were selected for analysis. (XLSX 15 kb)

Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the...

Background Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy...

Background RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a...

Additional file 5. List of relevant studies and the systematic map database to answer secondary question 1.