The top 20 drugs by the number of repurposing opportunities identified by PathFX.

Interviewee report of academic community response.

Physicians’ familiarity and comfort with the FDA drug approval process.

Variables considered in the analysis of determinants of functional day profile.

Literature appraisal criteria.

All four tests had 100% sensitivity.

Vaccine and Related Biological Products Advisory Committee (VRBPAC) discussion on the results submitted for the biologics license application (BLA) from the clinical development...

Common subcategories for petition denials on scientific and legal grounds.

Statistical analyses of utilization trends of olanzapine before and after federal False Claims Act settlement, using Poisson regression models, July 2004 to January 2011.

The number of distinct compound-target combinations screened in multiple assays, listed for increasing numbers of assays.

Bivariate analysis of the ratio between completed treatments and first scheduled dental appointment versus work process variables and professional profiles.

Frequency of favorable responses* to observed variables on planning of actions; health promotion and intersectoral actions; integral health care that composed latent subgroups:...

Shown are the top 16 highest scoring drug-target biclusters with more than one compound and more than one target. The number of drugs (cids) and targets is shown in columns 2...

Currently approved monoamine modulating antidepressant and anxiolytic pharmaceutics fail in over one third of patients due to delayed and variable therapeutic effect, adverse...

The terms ‘Jung CUI’ and ‘Jung Disease’ are terms extracted from [36] and represent the associations between drugs and diseases found the electronic health record.

Efficacy of oncological treatments approved by the FDA in 2011 and 2012 as evaluated by Fojo and collaborators (2014).

Appendix: Approved Orphan Products Dataset. (XLSX 92Â kb)

Spinal muscular atrophy (SMA) is a monogenic disorder caused by loss of function mutations in the survival motor neuron 1 gene, which results in a broad range of disease...

Crude and adjusted regression models of the variables associated with ratio between completed treatments and first scheduled dental appointments ≥ 1.

Repair and regeneration of critically injured peripheral nerves is one of the most challenging reconstructive surgeries. Currently available and FDA approved nerve guidance...