Median TPM values from RNA-Sequencing. Transcripts were ranked according to their median TPM value in the EWAS samples, with the highest expressed genes on top. (XLSX 1299 kb)

Results of the EpiDISH cell type deconvolution. Estimates for the different cell type fractions are given each for the EWAS samples and the OSCC samples, each also additionally...

Partial correlation between HIF3A methylation and metabolic indicators adjusted for age, gender and BMI.

Correlation of associated CpGs with association of transcripts. Shown are all CpGs with q < 0.15 that map to genes that were differentially expressed in smokers with a...

Results from the ANCOVA of OSCC samples in AHRR and CYP1B1. Listed are all CpGs within the genetic regions of AHRR and CYP1B1 (n = 202) to indicate absence of CpGs in the 450 k...

Excel table containing LungNet. (XLS 325 kb)

Characteristics of the analysed population.

Summary of sex-associated DMRs. Number of DMRs significantly hyper- and hypo-methylated in newborn girls compared to boys at FDR multiple testing threshold (q < 0.05), for...

Excel table containing the results of a GSEA on the target genes in LungNet. (XLS 242 kb)

Significantly methylated CpGs between long-term exposed samples with ADHD and sporadically exposed samples with ADHD. (XLSX 585Â kb)

Background Human diseases are commonly the result of multidimensional changes at molecular, cellular, and systemic levels. Recent advances in genomic technologies have enabled...

HIF3A DNA methylation values (in %) for each CpG unit in obese cases and controls.

Data sources and statistics for estimation of population attributable fractions (PAFs) in monozygotic twins.

General characteristics of the obese children and controls.

Global deaths attributed to exposure-risk factors for chronic diseases.

Results from the KEGG and Reactome Pathway Analyses of Differentially Expressed Genes. (XLSX 76 kb)

Additional file 3. Sex-associated CpGs in KORA F4 and the buccal cells study. The table includes CpGs significantly associated with sex in the KORA F4 and in the buccal cells...

Partial correlation between HIF3A methylation and metabolic indicators adjusted for age and gender.

Additional file 2. Results from discovery (KORA F4) and replication analyses (KORA F3, ALSPAC, EPICOR). The table includes respective Pearsonâ s rho and p-values for 391,885...

CpGs from the literature associated with SPY in our data. Results are shown for the ANCOVA with SPY for all CpGs with q < 0.15 in our EWAS that map to genes harbouring a...