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Predictors of atrial fibrillation in ibrutinib-treated CLL patients: a prospe...
Background Ibrutinib is an oral irreversible inhibitor of Bruton’s tyrosine kinase, indicated for the treatment of chronic lymphocytic leukaemia. The drug is generally well... -
MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma ...
The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear.... -
l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell ...
Aggressive nature killer cell leukemia (ANKL) is a mature NK-T cell lymphoma with worse prognosis, but optimal treatment is unclear. Therefore, we analyzed the efficacy of... -
Overexpression of CLC-3 is regulated by XRCC5 and is a poor prognostic biomar...
Background Recently, many potential prognostic biomarkers for gastric cancer (GC) have been identified, but the prognosis of advanced GC patients remains poor. Chloride channels... -
"Serial cfDNA assessment of response and resistance to EGFR-TKI for patients ...
Background Detecting epidermal growth factor receptor (EGFR) activating mutations in plasma could guide EGFR-tyrosine kinase inhibitor (EGFR-TKI) treatment for advanced... -
The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoieti...
Background The optimal monitoring schedules and cutoff minimal residual disease (MRD) levels for the accurate prediction of relapse at all time points after allogeneic... -
Platelet desialylation correlates with efficacy of first-line therapies for i...
Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many... -
Immune phenotypes predict survival in patients with glioblastoma multiforme
Background Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current... -
Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to conf...
Background Resistance to tamoxifen (TAM) frequently occurs in the treatment of estrogen receptor positive (ER+) breast cancer. Accumulating evidences indicate that transcription... -
Autologous cytokine-induced killer cell transfusion increases overall surviva...
Background Advanced pancreatic cancer (PC) has very poor prognosis with present treatments, thus necessitating continued efforts to find improved therapeutic approaches. Both... -
Cost-effectiveness of nivolumab in patients with advanced renal cell carcinom...
Background We evaluated the cost-effectiveness of nivolumab versus everolimus in patients with advanced renal cell carcinoma (RCC) from a US payer perspective. Methods A... -
Safety of pazopanib and sunitinib in treatment-naive patients with metastatic...
Background The international, phase 3 COMPARZ study demonstrated that pazopanib and sunitinib have comparable efficacy as first-line therapy in patients with advanced renal cell... -
High IKZF1/3 protein expression is a favorable prognostic factor for survival...
The aim of this study is to assess nucleoprotein expression of IKZF1/3 in patients with relapsed/refractory multiple myeloma (MM) who received lenalidomide-based therapy and... -
Haploidentical transplantation is associated with better overall survival whe...
Background Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in... -
Azacitidine front-line in 339 patients with myelodysplastic syndromes and acu...
Background The MDS-IWG and NCCN currently endorse both FAB and WHO classifications of MDS and AML, thus allowing patients with 20–30 % bone marrow blasts (AML20–30, formerly... -
EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediate...
Background Activated protein C/endothelial protein C receptor (APC/EPCR) axis is physiologically involved in anticoagulant and cytoprotective activities in endothelial cells.... -
Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chapero...
Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins. In recent years, the... -
Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter...
The efficacy and safety of chidamide, a new subtype-selective histone deacetylase (HDAC) inhibitor, have been demonstrated in a pivotal phase II clinical trial, and chidamide... -
Matched and mismatched unrelated donor compared to autologous stem cell trans...
Background Optimal post-remission strategy for patients with acute myeloid leukemia (AML) is matter of intense debate. Recent reports have shown stronger anti-leukemic activity... -
STARD13-correlated ceRNA network-directed inhibition on YAP/TAZ activity supp...
Background Targeting cancer stem cells is critical for suppressing cancer progression and recurrence. Finding novel markers or related pathways could help eradicate or diagnose...
