MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients. Electronic supplementary material The online version of this article (doi:10.1186/s13045-017-0402-6) contains supplementary material, which is available to authorized users.

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PID https://www.doi.org/10.1186/s13045-017-0402-6
PID pmc:PMC5264457
PID pmid:28122647
URL http://link.springer.com/content/pdf/10.1186/s13045-017-0402-6.pdf
URL https://mdanderson.elsevierpure.com/en/publications/mir-194-functions-as-a-tumor-suppressor-in-laryngeal-squamous-cel
URL https://doaj.org/toc/1756-8722
URL http://europepmc.org/articles/PMC5264457
URL http://link.springer.com/article/10.1186/s13045-017-0402-6
URL https://doi.org/10.1186/s13045-017-0402-6
URL https://link.springer.com/article/10.1186/s13045-017-0402-6
URL https://dx.doi.org/10.1186/s13045-017-0402-6
URL https://core.ac.uk/display/81707186
URL http://dx.doi.org/10.1186/s13045-017-0402-6
URL https://jhoonline.biomedcentral.com/articles/10.1186/s13045-017-0402-6
URL https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0402-6
URL https://academic.microsoft.com/#/detail/2582716876
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Access Right Open Access
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Author Pei Li
Author Yang Yang
Author Hui Liu
Author An-Kui Yang
Author Jin-Ming Di
Author Guang-Mou Tan
Author Hai-Feng Wang
Author Jian-Ge Qiu
Author Wen-Ji Zhang
Author Qi-Wei Jiang
Author Di-Wei Zheng
Author Yao Chen
Author Meng-Ning Wei
Author Jia-Rong Huang
Author Kun Wang
Author Zhi Shi, 0000-0002-8328-0305
Author Jin Ye
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Collected From Europe PubMed Central; PubMed Central; UnpayWall; Datacite; DOAJ-Articles; Crossref; Microsoft Academic Graph; CORE (RIOXX-UK Aggregator)
Hosted By Europe PubMed Central; SpringerOpen; Journal of Hematology & Oncology
Journal Journal of Hematology & Oncology, 10,
Publication Date 2017-01-25
Publisher BioMed Central
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Language English
Resource Type Article; UNKNOWN
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::f9783797be11bc8452bd04d0351eb5ce
Author jsonws_user
Last Updated 26 December 2020, 23:04 (CET)
Created 26 December 2020, 23:04 (CET)