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Genome-wide recruitment profiling of transcription factor Crz1 in response to...
Exposure of the budding Saccharomyces cerevisiae to an alkaline environment produces a robust transcriptional response involving hundreds of genes. Part of this response is... -
Processed_Data
Fig.1 The He number density for equilibrium He bubble at 300K. The green and red dots correspond to the unsaturated and saturated state, respectively. Fig.2 The pressure of... -
Additional File 2:
Table S1. Description of all the covariates used in the study. Table S2. Spearman correlations of all the covariates with four α-diversity metrics. Table S3. Results of... -
The chicken erythrocyte epigenome
Abstract Background Transcriptional regulation is impacted by multiple layers of genome organization. A general feature of transcriptionally active chromatin is sensitivity to... -
Adaptation of a RAS pathway activation signature from FF to FFPE tissues in c...
Abstract Background The KRAS gene is mutated in about 40 % of colorectal cancer (CRC) cases, which has been clinically validated as a predictive mutational marker of intrinsic... -
Probabilistic modeling of personalized drug combinations from integrated chem...
Abstract Background Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient... -
TSS-EMOTE, a refined protocol for a more complete and less biased global mapp...
Background Bacteria rely on efficient gene regulatory mechanisms to switch between genetic programs when they are facing new environments. Although this regulation can occur at... -
Association of the ACTN3 R577X (rs1815739) polymorphism with elite power spor...
Objective The special status accorded to elite athletes stems from their uncommon genetic potential to excel in world-class power sports (PS). Genetic polymorphisms have been... -
Lost Branches on the Tree of Life
Given that reproducibility is a pillar of scientific research, the preservation of scientific knowledge (underlying data) is of paramount importance. The standard of... -
Teaching the Fundamentals of Biological Data Integration Using Classroom Games
This article aims to introduce the nature of data integration to life scientists. Generally, the subject of data integration is not discussed outside the field of computational... -
Ten Simple Rules for Selecting a Bio-ontology
Biologists and bioinformaticians now look to ontologies or software that uses ontologies as a means of standardising the way data are described, queried, and interpreted.... -
The development and application of bioinformatics core competencies to improv...
Bioinformatics is recognized as part of the essential knowledge base of numerous career paths in biomedical research and healthcare. However, there is little agreement in the... -
Pearls Front Matter: Plant Virus Ecology
Human activity is causing new encounters between viruses and plants. Anthropogenic interventions include changing land use, decreasing biodiversity, trade, the introduction of... -
Detection and removal of biases in the analysis of next-generation sequencing...
Since the emergence of next-generation sequencing (NGS) technologies, great effort has been put into the development of tools for analysis of the short reads. In parallel,... -
Bayesian multivariate reanalysis of large genetic studies identifies many new...
Genome-wide association studies (GWAS) have now been conducted for hundreds of phenotypes of relevance to human health. Many such GWAS involve multiple closely-related... -
Life, the Universe, and Everything: An Interview with David Haussler
Among the pantheon of computer scientists who have framed our capacity to interpret DNA sequences stands David Haussler of the University of California, Santa Cruz (UCSC).... -
Design and Implementation of a Genomics Field Trip Program Aimed at Secondary...
With the rapid pace of advancements in biological research brought about by the application of computer science and information technology, we believe the time is right for... -
dedup_wf_001--951808e49ec5ba90142b95af024b4f09
The Prenatal Assessment of Genome and Exomes (PAGE) project is a UK-wide study aiming to gain a better understanding of genetic variants causing developmental problems during... -
The Complete Genome Sequence of Mycoplasma bovis Strain Hubei-1
Infection by Mycoplasma bovis (M. bovis) can induce diseases, such as pneumonia and otitis media in young calves and mastitis and arthritis in older animals. Here, we report the...
