BackgroundNon-invasive prenatal testing (NIPT) for Down’s syndrome (DS) using cell free fetal DNA in maternal blood has the potential to dramatically alter the way prenatal...

∧Degree of intellectual disability is based on all items of the SRZ.°Unstandardized regression weights.†Unstandardized regression weights adjusted for parental education and...

Abbreviation: SD – standard deviation. * Boys with DS compared to girls with DS. ∧Both parents born in the Netherlands.

*Calculated using the Fetal-fraction Optimized Risk of Trisomy Evaluation (FORTE) algorithm. TP  =  number of true positive results; FN  =  number of false negative results; TN...

Note: Mean values are presented with standard deviations in parentheses. *N = 20 for T1 VABS Score. 1Vineland Adaptive Behavior Composite Score; 2Child Behavior Checklist...

*For both unaffected and DS affected pregnancies. **As for invasive diagnostic tests. ***As for DS screening. DS  =  Down’s syndrome; NT  =  nuchal translucency; CVS  =...