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Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Background Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics. Here, we... -
Mosaic autosomal aneuploidies are detectable from single-cell RNAseq data.
Background Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic... -
Compendium of TCDD-mediated transcriptomic response datasets in mammalian mod...
Background 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of... -
Power-Laws and the Use of Pluripotent Stem Cell Lines
It is widely accepted that the (now reversed) Bush administration’s decision to restrict federal funding for human embryonic stem cell (hESC) research to a few “eligible” hESC... -
dedup_wf_001--3a68621187992366a08b9fa9c1bab3e9
Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful... -
CTCF maintains regulatory homeostasis of cancer pathways
Background CTCF binding to DNA helps partition the mammalian genome into discrete structural and regulatory domains. Complete removal of CTCF from mammalian cells causes...
