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Crystallographic data collection and refinement statistics.
*Values in parentheses are for highest-resolution shell.aRmerge = Σh Σi|Ii(h)−<I(h)>/|Σh Σi Ii(h), where I is the observed intensity and <I> is the average intensity... -
r37980778c78--8201ad78e37d1663129395d876399e0f
Allosteric modulators of the cannabinoid CB1 receptor have recently been reported as an alternative approach to modulate the CB1 receptor for therapeutic benefits. In this... -
Oxygen uptake, gross efficiency, cycle rate, heart rate, blood lactate, as we...
Oxygen uptake, gross efficiency, cycle rate, heart rate, blood lactate, as well as the level of significance during 4-minute submaximal roller ski skating (5% incline at 14... -
Binding of F0016 mAbs to PCSK9 WT and the D374Y variant as determined by SPR.
Binding of F0016 mAbs to PCSK9 WT and the D374Y variant as determined by SPR. -
Primers used in this study.
a Liu et al., 2011 [19]. b Ji et al., 2007 [20]. c Wei et al., 2010 [21]. d Noteborn et al., 2013 [22]. *Positions correspond to: IBDV (JQ684022), IBV (KJ425500), AEV... -
r37980778c78--36d6a6c8f648b0766cb6499622ebf86b
Adrenergic α2C receptor (ADRA2C) is an inhibitory modulator of the sympathetic nervous system. Knockout mice for this gene show physiological and behavioural alterations that... -
Summary of Results.
Summary of results of follicle number counts, mRNA analyses and oxidative stress measures in ovaries of offspring born to mothers undernourished during pregnancy (UNP), during... -
Data collection and refinement statistics.
1Statistics for data from the highest-resolution shell are shown in parentheses. 2 R sym =(ΣΣ|Ihkl−〈I〉|)/(ΣIhkl), where the average intensity <I> is taken... -
Development of 2‑(2-(3-(4-([<sup>18</sup>F]Fluoromethoxy‑<i>d</i><sub>2</sub>...
Phosphodiesterase 10A (PDE10A) is a newly identified therapeutic target for central-nervous-system disorders.... -
Oligonucleotides used in this study.
aSequences in upper case letters are derived from the genome sequences of H. pylori 26695 [25], H. hepaticus[32], C. jejuni[33] and W. succinogenes[34]. Sequences introduced for... -
New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and...
Cannabidiol (CBD) and cannabidiol dimethyl hephtyl (CBD-DMH) were hydrogenated to give four different epimers. The new derivatives were evaluated for their ability to modulate... -
Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9<i>H</i>-purin-6-yl]-4...
We report the structure−activity relationships, design, and synthesis of the novel cannabinoid type 1 (CB1) receptor antagonist 3a (CP-945,598). Compound 3a showed subnanomolar... -
r37980778c78--f6e30b0cd07324323243079d31d37416
Glutamine synthetase adenylyltranferase (ATase, EC 2.7.7.49) catalyzes the adenylylation and deadenylylation of glutamine synthetase (GS), regulating GS activity. The... -
r37980778c78--1e13d726e90796f167fd4fd4eacc3a18
Modulation of soluble guanylate cyclase (sGC) activity by nitric oxide (NO) involves two distinct steps. Low-level activation of sGC is achieved by the stoichiometric binding of... -
r37980778c78--d39f9e8ca0ca30b5adaee6f6961a3d63
We present the synthesis of ring-opening metathesis polymerization block polymers containing a ruthenium bipyridine luminescent block and a hydrophobic block and end-terminated... -
Modulation of Diacylglycerol Kinase θ Activity by α-Thrombin and Phospholipid...
Diacylglycerol kinase modulates the levels of diacylglycerol and phosphatidic acid, two critical lipid second messengers, yet little is known about the effects of cellular... -
Artificial Metalloglycoclusters: Compact Saccharide Shell to Induce High Lec...
Tris-bipyridine ferrous and ruthenium complexes carrying various saccharide appendages have been investigated to develop sensory systems for monitoring saccharide-binding... -
r37980778c78--340af0e491e60d31adc386c99f347867
A new anthracene dimer connected by two imidazolium moieties has been systematically designed and synthesized as a fluorescent chemosensor for selective binding of H2PO4- over... -
<i>Escherichia coli</i> Glutamine Synthetase Adenylyltransferase (ATase, EC 2...
Glutamine synthetase adenylyltranferase (ATase, EC 2.7.7.49) catalyzes the adenylylation and deadenylylation of glutamine synthetase (GS), regulating GS activity. The...
