New Cannabidiol Derivatives:  Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity

Cannabidiol (CBD) and cannabidiol dimethyl hephtyl (CBD-DMH) were hydrogenated to give four different epimers. The new derivatives were evaluated for their ability to modulate the production of reactive oxygen intermediates (ROI), nitric oxide (NO), and tumor necrosis factor (TNF-α) by murine macrophages, and for their binding to the cannabinoid receptor (CB1). Surprisingly, we found that these derivatives exhibit good binding to CB1. In addition hydrogenated CBD and CBD-DMH demonstrate bioactivities different from their original compounds.

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PID https://www.doi.org/10.1021/jm050709m.s001
PID pmid:16451075
PID https://www.doi.org/10.1021/jm050709m
URL https://pubs.acs.org/doi/pdf/10.1021/jm050709m
URL http://dx.doi.org/10.1021/jm050709m
URL https://pubs.acs.org/doi/10.1021/jm050709m
URL https://figshare.com/articles/journal_contribution/New_Cannabidiol_Derivatives_Synthesis_Binding_to_Cannabinoid_Receptor_and_Evaluation_of_Their_Antiinflammatory_Activity/3238768
URL https://www.ncbi.nlm.nih.gov/pubmed/16451075
URL https://academic.microsoft.com/#/detail/1986671176
URL https://dx.doi.org/10.1021/jm050709m
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Access Right Open Access
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Author Shimon Ben-Shabat
Author Lumír O. Hanuš
Author Galia Katzavian
Author Ruth Gallily
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Collected From Europe PubMed Central; figshare; Datacite; Crossref; Microsoft Academic Graph
Hosted By figshare; Journal of Medicinal Chemistry
Publication Date 2016-05-05
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Language English
Resource Type Other literature type; Article; UNKNOWN
keyword mesheuropmc.surgical procedures, operative
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::3dd5b77fbba3d50abe8aa0d7dcbd4062
Author jsonws_user
Last Updated 27 December 2020, 03:03 (CET)
Created 27 December 2020, 03:03 (CET)