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The diagnostic accuracy of the hand-held Raman spectrometer for the identific...
Abstract Background There is a need for accurate and field-applicable instruments for the evaluation of the quality of anti-malarial drugs. The aim of this study was to... -
Integrative assessment of brain and bone invasion in meningioma patients
Abstract Background Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain... -
Patients' preferences for involvement in the decision-making process for trea...
Abstract Background To assess factors associated with the preferred role of the attending ophthalmologist in the decision-making processes before treating diabetic retinopathy... -
Improving cooperation between general practitioners and dermatologists via te...
Abstract Background Internationally, teledermatology has proven to be a viable alternative to conventional physical referrals. Travel cost and referral times are reduced while... -
The impairment of small nerve fibers in severe sepsis and septic shock
Abstract Background A decrease of small nerve fibers in skin biopsies during the course of critical illness has been demonstrated recently. However, the diagnostic use of skin... -
Local measles vaccination gaps in Germany and the role of vaccination providers
Abstract Background Measles elimination in Europe is an urgent public health goal, yet despite the efforts of its member states, vaccination gaps and outbreaks occur. This study... -
Position statement on access to care in rare liver diseases: advancements of ...
Abstract The European Reference Network for rare liver diseases (ERN RARE-LIVER) is a Europe-wide network of paediatric and adult hepatologists from expert centres in close... -
Risk assessment of manual handling operations at work with the key indicator ...
Abstract Background Manual handling operations (MHO) are known to be risk factors for work-related upper limb disorders (WRULDs), e.g. symptoms and conditions such as carpal... -
Recommendations for patient screening in ultra-rare inherited metabolic disea...
Abstract Background Rare and ultra-rare diseases (URDs) are often chronic and life-threatening conditions that have a profound impact on sufferers and their families, but many... -
Increasing the treatment motivation of patients with somatic symptom disorder...
Abstract Background Therapeutic intervention programs for somatic symptom disorder (SSD) show only small-to-moderate effect sizes. These effects are partly explained by the... -
Increased cortical activation upon painful stimulation in fibromyalgia syndrome
Abstract Background Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain and associated symptoms. We investigated cerebral activation in FMS... -
Nosological delineation of congenital ocular motor apraxia type Cogan: an obs...
Abstract Background The nosological assignment of congenital ocular motor apraxia type Cogan (COMA) is still controversial. While regarded as a distinct entity by some... -
Prospective target assessment and multimodal prediction of survival for perso...
Abstract Background Personalized and risk-adapted treatment strategies in multiple myeloma prerequisite feasibility of prospective assessment, reporting of targets, and... -
Inflammatory profile in LRRK2-associated prodromal and clinical PD
Abstract Background There is evidence for a relevant role of inflammation in the pathogenesis of Parkinsonâ s disease (PD). Mutations in the LRRK2 gene represent the most... -
Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation o...
Abstract To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of >6 million single nucleotide... -
Physical activity promotion for multimorbid patients in primary care settings...
Abstract Background To date multimorbidity has not received much attention in health policies, even though multiple chronic diseases put high demands on the health care system... -
Nerve ultrasound characterizes AMN polyneuropathy as inhomogeneous and focal ...
Abstract Objective High-resolution nerve ultrasound (HRUS) is a painless tool to quickly evaluate peripheral nerve morphology in vivo. This study set out to characterize... -
CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
Abstract Background Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe... -
Long-term safety and efficacy of vismodegib in patients with advanced basal c...
Abstract Background In the primary analysis of the ERIVANCE BCC trial, vismodegib, the first US Food and Drug Administration–approved Hedgehog pathway inhibitor, showed... -
Image and perception of physicians as barriers to inter-disciplinary cooperat...
Abstract Background In the German rehabilitation system, primary care physicians (PCPs), occupational health physicians (OPs), and rehabilitation physicians (RPs) fulfill...
