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Domino Coupling Relay Approach to Polycyclic Pyrrole-2-carboxylates
CuBr2-catalyzed three-component coupling of N-benzylallylamine, ethyl glyoxalate, and terminal alkynes afforded glycine-tethered 1,6-enynes, which were further transformed into... -
Total Synthesis of (±)-Chartelline C
The first total synthesis of (±)-chartelline C in a concise 10-step sequence is reported. Highlights of the completion of this decades-old puzzle include (1) chemo- and... -
r37980778c78--2b1e8129802794b4525918ef8a2c38c0
A new strategy involving Ugi-Smiles coupling followed by ring-closure metathesis is described herein for the preparation of pyrimidine-fused heterocyclic scaffolds. The scope of... -
Extending Pummerer Reaction Chemistry: Application to the Assembly of the Pen...
A pentacyclic model system featuring the trans azabicyclo[3.3.0]octane unit of dibromopalau’amine was prepared with complete diastereoselectivity in the polycyclic core from a... -
Practical Method for Transforming Alkynes into α-Diketones.
Oxidation of alkynes to α-dicarbonyl derivatives through a convenient one-pot procedure via a Bronsted acid-promoted “hydration” and a DMSO-based oxidation sequence has been... -
r37980778c78--436d63fb126a12f2ca2514b116285ceb
An enantioselective strategy to the spirocyclic core found in the oroidin-derived family of bisguanidine marine alkaloids has been devised, premised on a biosynthetic proposal.... -
r37980778c78--c851b432545cf32a2a75d7bb879b83db
The synthesis of tetracyclic polyhydroxyquinones 5a and 5b was achieved through a sequence involving two Diels−Alder reactions with 1-methoxy-1,3-cyclohexadiene: the first with... -
Deciphering the Structural Transformations during Nickel Oxyhydroxide Electro...
The phases present in the positive nickel oxyhydroxide electrode (NOE) under standard operation conditions, that is, β-Ni(OH)2 and β-NiOOH, were studied by powder diffraction... -
A New Layered Silicate with Structural Motives of Silicate Zeolites: Synthesi...
A new layered silicate, RUB-51, [Si12O24(OH)4][C6H5CH2N(CH3)3]4, was synthesized from hydrothermal experiments using benzyl trimethylammonium hydroxide as the... -
r37980778c78--8b8a5ae28d3bb7d37a2ca2922ea2308e
The synthesis and structural characterization of 15R-, 8H-, 6H‘-, and 10H-BaMnO3-x and 9R-Ba0.875Sr0.125MnO3 is described. Neutron powder diffraction data reveal a strong... -
Revisiting the Ullmann−Ether Reaction: A Concise and Amenable Synthesis of N...
A concise synthesis of a series of novel dibenzoxepino[4,5-d]pyrazoles was accomplished by implementation of an intramolecular Ullmann-ether reaction on... -
Enantioselective Strategy to the Spirocyclic Core of Palau'amine and Related ...
An enantioselective strategy to the spirocyclic core found in the oroidin-derived family of bisguanidine marine alkaloids has been devised, premised on a biosynthetic proposal.... -
Genetic affinities among the historical provinces of Romania and Central Euro...
Background: As a major crossroads between Asia and Europe, Romania has experienced continuous migration and invasion episodes. The precise routes may have been shaped by the... -
r37980778c78--fcef622755385a0d6ce131b41c87a1ea
Artificial transcription factors targeting any desired genes are very attractive but require specific DNA binding domains in order to address a single site for each gene... -
r37980778c78--f427978cee3bbb3c3e1923ab639a3fd7
The introduction of sterically isolating ortho-trialkylsilyl, -aryldialkylsilyl, and -diarylalkylsilyl substituents onto the structurally preorganized... -
Enantioselective Total Synthesis of Aspergillide C
The first enantioselective total synthesis of aspergillide C, a cytotoxic 14-membered macrolide isolated from the marine-derived fungus Aspergillus ostianus, has been... -
r37980778c78--325fe372c39b2d3e78bd8ef6b5e53851
A mechanism of the Au-catalyzed cycloisomerization of propargylpyridines has been investigated. Both DFT computational and experimental results strongly support generation of a... -
Polymer-Supported Synthesis of Regioregular Head-to-Tail-Coupled Oligo(3-aryl...
The solid-phase synthesis of regioregular head-to-tail-coupled oligo(3-arylthiophene)s has been achieved in high yield and purity by using a traceless silyl ether linkage. In... -
r37980778c78--b2b79e004106aa9ee47073d0a69eeb71
Alkylidene indane and ring-expanded scaffolds have been prepared using an enantioselective crotylation/Heck cyclization sequence. Further diversification using consecutive... -
<i>anti</i>-Oligoannelated THF Moieties: Synthesis via <i>Push−Pull</i>-Subst...
The first synthesis of anti-fused oligoannelated THF moieties is reported. The key transformation of the synthetic sequence, consisting of cyclopropanation, reduction and...
