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Altering pyrroloquinoline quinone nutritional status modulates mitochondrial,...
We have reported that pyrroloquinoline quinone (PQQ) improves reproduction, neonatal development, and mitochondrial function in animals by mechanisms that involve mitochondrial... -
Beaming into the rat world: enabling real-time intereaction between rat and h...
Immersive virtual reality (IVR) typically generates the illusion in participants that they are in the displayed virtual scene where they can experience and interact in events as... -
Challenges in Translational Research: The Views of Addiction Scientists
Objectives To explore scientists' perspectives on the challenges and pressures of translating research findings into clinical practice and public health policy. Methods... -
Inclusion of Ethical Issues in Dementia Guidelines: A Thematic Text Analysis
Background Clinical practice guidelines (CPGs) aim to improve professionalism in health care. However, current CPG development manuals fail to address how to include ethical... -
How can journals respond to threats of libel litigation?
The mere suggestion of litigation can bias the medical literature by affecting editorial decisions. Libel threats are sometimes used by those with significant financial interest... -
Medical Complicity in Torture at Guantánamo Bay: Evidence Is the First Step T...
Vincent Iacopino and Stephen Xenakis review case records of nine individuals imprisoned at Guantánamo Bay which indicate that medical personnel assigned to the US Department of... -
What are fair study benefits in international health research? Consulting com...
Background Planning study benefits and payments for participants in international health research in low- income settings can be a difficult and controversial process, with... -
Publication Bias in Laboratory Animal Research: A Survey on Magnitude, Driver...
Context: Publication bias jeopardizes evidence-based medicine, mainly through biased literature syntheses. Publication bias may also affect laboratory animal research, but... -
Fostering critical thinking, reasoning, and argumentation skills through bioe...
Developing a position on a socio-scientific issue and defending it using a well-reasoned justification involves complex cognitive skills that are challenging to both teach and... -
The need for randomization in animal trials: an overview of systematic reviews
Background and Objectives: Randomization, allocation concealment, and blind outcome assessment have been shown to reduce bias in human studies. Authors from the Collaborative... -
Survey of Canadian Animal-Based Researchers' Views on the Three Rs: Replaceme...
The ‘Three Rs’ tenet (replacement, reduction, refinement) is a widely accepted cornerstone of Canadian and international policies on animal-based science. The Canadian Council... -
A Place to Hide in the Home-Cage Decreases Yolk Androgen Levels and Offspring...
International audience; An animal's emotional responses are the result of its cognitive appraisal of a situation. This appraisal is notably influenced by the possibility of an... -
What parents of children who have received emergency care think about deferri...
OBJECTIVE: To investigate parents' views about deferred consent to inform management of trial disclosure after a child's death. METHODS: A postal questionnaire survey was... -
Jumping without Using Legs: The Jump of the Click-Beetles (Elateridae) Is Mor...
To return to their feet, inverted click-beetles (Elateridae) jump without using their legs. When a beetle is resting on its dorsal side, a hinge mechanism is locked to store... -
Secure Surveillance of Antimicrobial Resistant Organism Colonization or Infec...
Background There is stigma attached to the identification of residents carrying antimicrobial resistant organisms (ARO) in long term care homes, yet there is a need to collect... -
Relative solidarity: Conceptualising communal participation in genomic resear...
OBJECTIVE: As genomic research gathers momentum in sub-Saharan Africa, it has become increasingly important to understand the reasons why individuals wish to participate in this... -
Diving-flight aerodynamics of a peregrine falcon (Falco peregrinus)
This study investigates the aerodynamics of the falcon Falco peregrinus while diving. During a dive peregrines can reach velocities of more than 320 km h−1. Unfortunately, in... -
Regression of Moral Reasoning during Medical Education: Combined Design Study...
BACKGROUND: Moral reasoning is important for developing medical professionalism but current evidence for the relationship between education and moral reasoning does not clearly... -
Industry-Sponsored Research: A More Comprehensive Alternative
In his letter [1] Dr. Mansfield has raised a debatable issue: “If the CRC [Collegiate Research Council] is a single international monopoly how could the risk of corruption and... -
Why Has the Number of Scientific Retractions Increased?
Background The number of retracted scientific publications has risen sharply, but it is unclear whether this reflects an increase in publication of flawed articles or an...
