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Complete Stereochemistry of Tetrafibricin.
With use of the NMR databases in achiral and chiral solvents, the complete stereochemistry of tetrafibricin (1) has been elucidated without degradation of the carbon framework. -
Intercalative Nanohybrids of Nucleoside Monophosphates and DNA in Layered Met...
Intercalative Nanohybrids of Nucleoside Monophosphates and DNA in Layered Metal Hydroxide -
Synthesis and Preliminary Biological Studies of 3-Substituted Indoles Accesse...
A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The... -
Enantioselective Total Synthesis of a Potent Antitumor Antibiotic, Fredericam...
The asymmetric total synthesis of both enantiomers of the potent antitumor antibiotic fredericamycin A (1) is detailed based on the protocol for the construction of its... -
Direct Electroreductive Preparation of Indolines and Indoles from Diazonium S...
Indolines and indoles are prepared for the first time by direct electrochemical reduction of arenediazonium salts. -
Mechanistic Studies of the tRNA-Modifying Enzyme QueA: A Chemical Imperative...
The enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) catalyzes the penultimate step in the biosynthesis of the tRNA nucleoside queuosine, a unique ribosyl... -
Ab Initio Study of the Carbon-to-Carbon Identity Proton Transfer from Ketene ...
Ab Initio Study of the Carbon-to-Carbon Identity Proton Transfer from Ketene to Its Anion in the Gas Phase -
Diverse Reactivity Manifolds of Alkynyl Enone- and Alkynyl Enal-Derived Nicke...
Diverse Reactivity Manifolds of Alkynyl Enone- and Alkynyl Enal-Derived Nickelacycles: Discovery of Nickel-Promoted [3+2] and [2+1] Cycloadditions -
Design and Self-Assembly of Cavity-Containing Rectangular Grids
Design and Self-Assembly of Cavity-Containing Rectangular Grids -
Synthesis of the First Corrolazine: A New Member of the Porphyrinoid Family
Synthesis of the First Corrolazine: A New Member of the Porphyrinoid Family -
Ruthenium-Catalyzed [2 + 2] Cycloadditions of Ynamides.
Ruthenium-catalyzed [2 + 2] cycloadditions between norbornene and ynamides were investigated. The ynamide moiety was found to be compatible with the ruthenium-catalyzed... -
Low Temperature CO Oxidation over Unsupported Nanoporous Gold
Supported Au nanoclusters are well-known for their unusual properties in catalysis. We describe here that nanostructured porous Au made via dealloying represents a new class of... -
Polymer-Induced Heteronucleation of Tolfenamic Acid: Structural Investigation...
The nonsteroidal anti-inflammatory drug (NSAID) tolfenamic acid (TA), previously thought to be dimorphic, is demonstrated to have at least five polymorphs. The new forms were... -
DFT Study of Pericyclic Reaction Cascades in the Synthesis of Antibiotic TAN-...
DFT calculations show that aromatic and bis-methoxy substituent effects in a synthetic precursor of TAN-1085 strongly favor a [1,7] sigmatropic hydrogen shift over the 6π... -
Synthesis of Nucleoside Dimers Bridged on Ribose with a Butadiynyl Group
The nucleoside dimer linked by a butadiynediyl group at C-3‘β may serve as a building block for the preparation of backbone-modified oligonucleotides for DNA repair or mutation... -
Unique Ionic Iodine Atom Transfer Cyclization: A New Route to Iodomethylated...
Pyrrolidines and bicyclic pyrrolidine derivatives can effectively be synthesized from γ-iodoolefins using commercially available chloramine-T (CT) as a nitrogen source. The... -
Design of Brønsted Acid-Assisted Chiral Brønsted Acid Catalyst Bearing a Bis(...
A new Brønsted acid-assisted chiral Brønsted (chiral BBA) acid catalyst (1) was developed by substituting a hydroxy group of optically active 1,1‘-bi(2-naphthol) with a stronger... -
A Fluorescent Sensor with High Selectivity and Sensitivity for Potassium in W...
This communication describes a new optical sensor suitable for practical measurement of extracellular (serum or whole blood) potassium. The sensor responds rapidly and... -
Catalysis of Phosphorus(V)-Mediated Transformations: Dichlorination Reactions...
A stereospecific triphenylphosphine oxide-catalyzed 1,2-dichlorination reaction of epoxides has been developed. The reaction is effective for a range of terminal and internal... -
Clathration-Induced Asymmetric Transformation of Cefadroxil
The cephalosporin antibiotic Cefadroxil can be epimerized at the α-carbon of its amino acid side chain using pyridoxal as the mediator. By clathration with...
