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The impact of genomic selection on genetic diversity and genetic gain in thre...
Abstract Background In France, implementation of genomic evaluations in dairy cattle breeds started in 2009 and this has modified the breeding schemes drastically. In this... -
Development of a promoter shutoff system in <i>Aspergillus oryzae</i> using a...
Promoter shutoff is a general method for analyzing essential genes, but in the fungus Aspergillus oryzae, no tightly repressed promoters have been reported. To overcome the... -
Acute severe paediatric asthma: study protocol for the development of a core ...
Abstract Background Acute severe childhood asthma is an infrequent, but potentially life-threatening emergency condition. There is a wide range of different approaches to this... -
Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
Differences in reported sepsis incidence according to study design: a literat...
Abstract Background Sepsis and severe sepsis are common conditions in hospital settings, and are associated with high rates of morbidity and mortality, but reported incidences... -
Pleural effusion from intrathoracic migration of a ventriculo-peritoneal shun...
Abstract Background Pleural effusion is a rare complication of ventriculo-peritoneal (VP) cerebrospinal fluid (CSF) shunting and its diagnosis is difficult in patients with... -
Twenty-five years of optical coherence tomography: the paradigm shift in sens...
Optical coherence tomography (OCT) has become one of the most successful optical technologies implemented in medicine and clinical practice mostly due to the possibility of... -
Effects of very early start of norepinephrine in patients with septic shock: ...
Abstract Background Optimal timing for the start of vasopressors (VP) in septic shock has not been widely studied since it is assumed that fluids must be administered in... -
Data quality and feasibility of the Experience Sampling Method across the spe...
Abstract Background Due to a number of methodological advantages and theoretical considerations, more and more studies in clinical psychology research employ the Experience... -
Borderline personality disorder and prior suicide attempts define a severity ...
Abstract Background Borderline personality disorder (BPD) and history of prior suicide attempt (SA) have been shown to be high predictors for subsequent suicide. However, no... -
Patternable particle microarray utilizing controllable particle delivery
Abstract In this study, we demonstrate an on-demand delivering and sequential arraying of single microparticles utilizing multiple pneumatic pressure-driven elastomer valves and... -
CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cl...
Abstract Background The CRISPR/dCas9 system is a powerful tool to activate the transcription of target genes in eukaryotic or prokaryotic cells, but lacks assays in complex... -
Correlates of knee bone marrow lesions in younger adults
Abstract Background Subchondral bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain and structural progression in... -
Efficient production of extracellular pullulanase in Bacillus subtilis ATCC60...
Abstract Background Bacillus subtilis has been widely used as a host for heterologous protein expression in food industry. B. subtilis ATCC6051 is an alternative expression host... -
A method for sensitivity analysis to assess the effects of measurement error ...
Abstract Background Measurement error in self-reported dietary intakes is known to bias the association between dietary intake and a health outcome of interest such as risk of a... -
Next-generation sequencing analysis of receptor-type tyrosine kinase genes in...
Abstract Background Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to... -
Reduction of spherical-aberration impact in microscopy by wavefront coding
In modern high-NA optical scanning instruments, like scanning microscopes, the refractive-index mismatch between the sample and the immersion medium introduces a significant... -
Cherenkov luminescence imaging is a fast and relevant preclinical tool to ass...
Abstract Purpose Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems... -
Using predicate and provenance information from a knowledge graph for drug ef...
Abstract Background Biomedical knowledge graphs have become important tools to computationally analyse the comprehensive body of biomedical knowledge. They represent knowledge...
