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Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Six-month adherence to Statin use and subsequent risk of major adverse cardio...
Abstract Background The evidence of adherence to statin decreasing risk of major adverse cardiovascular events (MACEs) is still lack among patients discharged with acute... -
Haploidentical allograft is superior to matched sibling donor allograft in er...
Abstract Background This study compared the effects of pre-transplantation minimal residual disease (pre-MRD) on outcomes in AML patients who underwent human leukocyte... -
Effect of a short course of iron polymaltose on acquisition of malarial paras...
Abstract Background Concern exists about the safety of iron supplementation given to individuals in malarious areas. The possible unfavourable impact of iron supplementation on... -
Role of mesenchymal stem cells, their derived factors, and extracellular vesi...
Abstract Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver... -
Characterization and pathogenesis of aerosolized eastern equine encephalitis ...
Abstract Background Licensed antiviral therapeutics and vaccines to protect against eastern equine encephalitis virus (EEEV) in humans currently do not exist. Animal models that... -
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inh...
Abstract Background Glossogyne tenuifolia (GT) (Hsiang-ju) is a Chinese herbal medicine previously exhibited an anti-inflammatory activity. This study aimed to investigate the... -
Comparing clinician descriptions of frailty and geriatric syndromes using ele...
Abstract Background Geriatric syndromes, including frailty, are common in older adults and associated with adverse outcomes. We compared patients described in clinical notes as... -
A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, ...
Abstract Background Hepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin... -
Resistance of Staphylococcus aureus to antimicrobial agents in Ethiopia: a me...
Abstract Background Emergence of antimicrobial resistance by Staphylococcus aureus has limited treatment options against its infections. The purpose of this study was to... -
Analytical characteristics and comparative evaluation of Aptima HCV quant Dx ...
Abstract Background The Aptima HCV Quant Dx assay (Aptima assay) is a fully automated quantitative assay on the Panther® system. This assay is intended for confirmation of... -
Lymphoma InterVEntion (LIVE) – patient-reported outcome feedback and a web-ba...
Abstract Background Patients with lymphoma are at risk of experiencing adverse physical and psychosocial problems from their cancer and its treatment. Regular screening of these... -
Development and evaluation of adsorption sheet (HD safe sheet-U) using active...
Abstract Background Certain amount of anticancer drugs is excreted in the urine of patients receiving anticancer drugs, and urinary scattering including anticancer drugs at... -
Maternal blood contamination of collected cord blood can be identified using ...
Abstract Background Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a... -
Cardiovascular risk factors are major determinants of thrombotic risk in pati...
Abstract Background Patients with the lupus anticoagulant (LA) are at an increased risk of thrombotic events, which in turn increase the risk of death. Understanding the...
