Haploidentical allograft is superior to matched sibling donor allograft in eradicating pre-transplantation minimal residual disease of AML patients as determined by multiparameter flow cytometry: a retrospective and prospective analysis

Abstract Background This study compared the effects of pre-transplantation minimal residual disease (pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched sibling donor transplantation (MSDT) or who received unmanipulated haploidentical allografts. Methods A retrospective study (n = 339) and a prospective study (n = 340) were performed. MRD was determined using multiparameter flow cytometry. Results Either after retrospective or prospective analysis, patients with negative pre-MRD (pre-MRDneg) had a lower incidence of relapse than those with positive pre-MRD (pre-MRDpos) in MSDT settings (P

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PID https://www.doi.org/10.6084/m9.figshare.c.3818077
PID https://www.doi.org/10.6084/m9.figshare.c.3818077.v1
URL http://dx.doi.org/10.6084/m9.figshare.c.3818077.v1
URL http://dx.doi.org/10.6084/m9.figshare.c.3818077
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Author Chang, Ying-Jun
Author Wang, Yu
Author Liu, Yan-Rong
Author Xu, Lan-Ping
Author Zhang, Xiao-Hui
Author Chen, Huan
Author Chen, Yu-Hong
Author Wang, Feng-Rong
Author Han, Wei
Author Sun, Yu-Qian
Author Yan, Chen-Hua
Author Tang, Fei-Fei
Author Mo, Xiao-Dong
Author Liu, Kai-Yan
Author Huang, Xiao-Jun
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Collected From Datacite
Hosted By figshare
Publication Date 2017-01-01
Publisher Figshare
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Language UNKNOWN
Resource Type Collection
keyword FOS: Biological sciences
keyword FOS: Clinical medicine
system:type other
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Source https://science-innovation-policy.openaire.eu/search/other?orpId=dedup_wf_001::bd56d6c41195f441b2ba760efc2e8f5a
Author jsonws_user
Last Updated 19 December 2020, 17:48 (CET)
Created 19 December 2020, 17:48 (CET)