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Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
Assessment of global DNA methylation in the first trimester fetal tissues exp...
Abstract Aims Maternal cigarette smoking during pregnancy increases the risk of negative health consequences for the exposed child. Epigenetic mechanisms constitute a likely... -
Identification of plasma microRNA expression changes in multiple system atrop...
Abstract MicroRNAs (miRNAs) are endogenous small (18–25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The... -
Activation of MET pathway predicts poor outcome to cetuximab in patients with...
Abstract Background Activation of the MET oncogene promotes tumor growth, invasion and metastasis in several tumor types. Additionally, MET is activated as a compensatory... -
pH-mediated upregulation of AQP1 gene expression through the Spi-B transcript...
Abstract Background Bicarbonate-based peritoneal dialysis (PD) fluids enhance the migratory capacity and damage-repair ability of human peritoneal mesothelial cells by... -
Isolation and identification of a TetR family protein that regulates the biod...
Abstract Biodesulfurization helps in removal of sulfur from organosulfur present in petroleum fractions. All microorganisms isolated to date harbor a desulfurization operon... -
Distinct core promoter codes drive transcription initiation at key developmen...
Abstract Background Development is largely driven by transitions between transcriptional programs. The initiation of transcription at appropriate sites in the genome is a key... -
Biotransformation of keratin waste to amino acids and active peptides based o...
Abstract Background Keratin is the primary constituent of the vertebrate epidermis and epidermal appendages, as well as the main waste product generated during poultry... -
Prognostic significance of supradiaphragmatic lymph node metastasis detected ...
Abstract Background Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using 18F-FDG positron emission tomography/computed tomography (PET/CT) in... -
Comparative transcriptome analysis reveals gene network regulating cadmium up...
Abstract Background Iron (Fe) is an essential element for plant growth and development, whereas cadmium (Cd) is non-essential and highly toxic. Previous studies showed that Fe... -
A transgenerational role of the germline nuclear RNAi pathway in repressing h...
Abstract Background Environmental stress-induced transgenerational epigenetic effects have been observed in various model organisms and human. The capacity and mechanism of such... -
TSS-EMOTE, a refined protocol for a more complete and less biased global mapp...
Abstract Background Bacteria rely on efficient gene regulatory mechanisms to switch between genetic programs when they are facing new environments. Although this regulation can... -
Confident gene activity prediction based on single histone modification H2BK5...
Abstract Background The histones in the core of nucleosomes may be subject to covalent post-transcriptional modifications. These modifications are thought to correlate with and... -
The Dictyostelium discoideum homologue of Twinkle, Twm1, is a mitochondrial D...
Abstract Background DNA replication requires contributions from various proteins, such as DNA helicases; in mitochondria Twinkle is important for maintaining and replicating... -
A novel pyruvate kinase and its application in lactic acid production under o...
Abstract Background Pyruvate kinase (Pyk) catalyzes the generation of pyruvate and ATP in glycolysis and functions as a key switch in the regulation of carbon flux distribution.... -
Clinical and subclinical endometritis induced alterations in bovine endometri...
Abstract Background Clinical and subclinical endometritis are known to affect the fertility of dairy cows by inducing uterine inflammation. We hypothesized that clinical or... -
Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis prog...
Abstract Background SIRT1 histone deacetylase acts on many epigenetic and non-epigenetic targets. It is thought that SIRT1 is involved in oocyte maturation; therefore, the... -
Ambient particulate matter and microRNAs in extracellular vesicles: a pilot s...
Abstract Background Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to... -
Identification of a putative methyltransferase gene of Babesia bigemina as a ...
Abstract Background Bovine babesiosis is caused by apicomplexan pathogens of the genus Babesia such as B. bigemina and B. bovis. These tick-borne pathogens have a complex... -
Meta-analysis of human gene expression in response to Mycobacterium tuberculo...
Abstract Background With the global emergence of multi-drug resistant strains of Mycobacterium tuberculosis, new strategies to treat tuberculosis are urgently needed such as...
