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Broad phenotypic spectrum and genotype-phenotype correlations in GMPPB-relate...
Background Dystroglycanopathy (α-DG) is a relatively common, clinically and genetically heterogeneous category of congenital forms of muscular dystrophy (CMD) and limb-girdle... -
IgM response against amyloid-beta in aging: a potential peripheral protective...
Background The immune system plays a major role in the pathogenesis of age-related dementia, including Alzheimer’s disease (AD). An insight into age-associated changes in the... -
Co-trimoxazole versus azithromycin for the treatment of undifferentiated febr...
Background Undifferentiated febrile illness (UFI) includes typhoid and typhus fevers and generally designates fever without any localizing signs. UFI is a great therapeutic... -
Development and validation of a prognostic model for recurrent glioblastoma p...
Background Predictive markers and prognostic models are required in order to individualize treatment of recurrent glioblastoma (GBM) patients. Here, we sought to identify... -
Veteran-centered barriers to VA mental healthcare services use.
Background Some veterans face multiple barriers to VA mental healthcare service use. However, there is limited understanding of how veterans’ experiences and meaning systems... -
"Somatosensory abnormalities in Chinese patients with painful temporomandibul...
Background The somatosensory phenotype of Chinese temporomandibular disorders (TMD) patients is not sufficiently studied with the use of contemporary techniques and guidelines.... -
Associations of mutually exclusive categories of physical activity and sedent...
Background Both physical activity and sedentary behaviour have been individually associated with health, however, the extent to which the combination of these behaviours... -
Natalizumab treatment reduces L-selectin (CD62L) in CD4+ T cells
Background The purpose of this research was to validate the low expression of L-selectin (CD62L) in natalizumab (NTZ)-treated patients. CD62L is involved in rolling and... -
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Background In 2011, the UK physical activity guidelines were updated to include recommendations for muscle strengthening and balance & coordination (at least two sessions of... -
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Previously depressed individuals experience disturbances in affect. Affective disturbances may be related to visual mental imagery, given that imagery-based processing of... -
Haploidentical transplantation is associated with better overall survival whe...
Background Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in... -
Key traveller groups of relevance to spatial malaria transmission: a survey o...
Background As malaria prevalence declines in many parts of the world due to widescale control efforts and as drug-resistant parasites begin to emerge, a quantitative... -
A discrete cluster of urinary biomarkers discriminates between active systemi...
Background Management of lupus nephritis (LN) would be greatly aided by the discovery of biomarkers that accurately reflect changes in disease activity. Here, we used a... -
Patterns of symptom development in patients with motor neuron disease
Objective: To investigate whether symptom development in motor neuron disease (MND) is a random or organized process. Methods: Six hundred patients with amyotrophic lateral... -
Availability of healthier vs. less healthy food and food choice: an online ex...
Background Our environments shape our behaviour, but little research has addressed whether healthier cues have a similar impact to less healthy ones. This online study examined... -
Extraction of respiratory signals from the electrocardiogram and photoplethys...
line-height:13.7pt">INTRODUCTION: Respiratory rate (RR) is an important indicator of clinical deterioration, but is notoriously difficult to monitor in ambulatory patients.... -
Sphenopalatine ganglion stimulation for cluster headache, results from a larg...
Background Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established... -
Trends in risk factors for coronary heart disease in the Netherlands.
Background Favourable trends in risk factor levels in the general population may partly explain the decline in coronary heart disease (CHD) morbidity and mortality. Our aim was... -
Benefits, barriers and opinions on multidisciplinary team meetings:a survey i...
Background Case review and discussion at multidisciplinary team meetings (MDTMs) have evolved into standard practice in cancer care with the aim to provide evidence-based... -
STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily ...
Background The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the...
