-
p38α MAPK disables KMT1A-mediated repression of myogenic differentiation program
Abstract Background Master transcription factor MyoD can initiate the entire myogenic gene expression program which differentiates proliferating myoblasts into multinucleated... -
The potential value of serum pepsinogen for the diagnosis of atrophic gastrit...
Abstract Background The aim of this study is to assess the validity of the measurement of pepsinogen as a screening test for chronic atrophic gastritis (AG) in health check-up... -
ITGA6 is directly regulated by hypoxia-inducible factors and enriches for can...
Abstract Background Hypoxia-inducible factors (HIFs) are well-established mediators of tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several... -
A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coor...
Abstract Background Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes... -
Improvements in psoriasis within different body regions vary over time follow...
Background: Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17 A. Objective: Examine the efficacy of ixekizumab in clearing psoriasis... -
Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b ex...
Abstract Background Functioning of the adult nervous system depends on the establishment of neural circuits during embryogenesis. In vertebrates, neurons that make up motor... -
Granatum: a graphical single-cell RNA-Seq analysis pipeline for genomics scie...
Abstract Background Single-cell RNA sequencing (scRNA-Seq) is an increasingly popular platform to study heterogeneity at the single-cell level. Computational methods to process... -
Single-cell ATAC-seq signal extraction and enhancement with SCATE
Abstract Single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) is the state-of-the-art technology for analyzing genome-wide regulatory landscapes in... -
An atypical HLH transcriptional regulator plays a novel and important role in...
Abstract Background In soft fruits, the differential expression of many genes during development and ripening is responsible for changing their organoleptic properties. In... -
Aqueous humor levels of TGFβ2 and SFRP1 in different types of glaucoma
Abstract Background To assess bioactive transforming growth factor-β2 (TGFβ2) and secreted frizzled-related protein-1 (SFRP1) levels in aqueous humor (AH) of different types of... -
Arbutin encapsulated micelles improved transdermal delivery and suppression o...
Abstract Background Hyperpigmentation is a skin disorder characterized by elevated production of melanin. Current treatment approaches mainly rely on the application of skin... -
Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid ang...
Abstract Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid β (Aβ) protein in the cerebral vasculature and poses a major risk factor for the... -
Mutational signatures: experimental design and analytical framework
Abstract Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and... -
Protective Effect of Intravitreal Administration of Exosomes Derived from Mes...
Purpose: Exosomes derived from human mesenchymal stem cells (hMSCs) cultured under hypoxic conditions contain proteins and growth factors that promote angiogenesis. This study... -
Regional variation in antibiotic prescribing among medicare part D enrollees,...
Abstract Background Antibiotics are among the most widely prescribed medications. The geographic variation in antibiotic prescribing patterns and associated costs among Medicare... -
High-level extracellular production of recombinant nattokinase in Bacillus su...
Abstract Background Nattokinase (NK), which is a member of the subtilisin family, is a potent fibrinolytic enzyme that might be useful for thrombosis therapy. Extensive work has... -
Activation and polarization of circulating monocytes in severe chronic obstru...
Abstract Background The ability of circulating monocytes to develop into lung macrophages and promote lung tissue damage depends upon their phenotypic pattern of differentiation... -
TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-depend...
Abstract Background Dysregulated transforming growth factor β (TGFβ) signaling is implicated in osteoarthritis development, making normalizing TGFβ signaling a possible therapy.... -
A comparison of the enzymatic properties of three recombinant isoforms of thr...
Abstract Background Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has... -
Expression of NK genes that are not part of the NK cluster in the onychophora...
Abstract Background NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. They are typically divided into...
