Nanoparticle-Based Sensing of Glycan−Lectin Interactions

Here we present the first report on nanoparticle-based biosensing of glycan markers of diseases. The protocol relies on the competition between a nanocrystal (CdS)-tagged sugar and the target sugar for the binding sites of surface-confined lectin and monitoring the extent of competition through highly sensitive electrochemical detection of the captured nanocrystal. This development is expected to allow decentralized detection of carbohydrate moieties and lectin−carbohydrate interactions to be performed more rapidly, sensitively, inexpensively, and reliably.

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PID https://www.doi.org/10.1021/ja063565p.s001
URL https://figshare.com/articles/journal_contribution/Nanoparticle_Based_Sensing_of_Glycan_Lectin_Interactions/3065827
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Access Right Open Access
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Author Dai, Zong
Author Kawde, Abdel-Nasser
Author Xiang, Yun
Author La Belle, Jeffrey T.
Author Gerlach, Jared
Author Bhavanandan, Veer P.
Author Joshi, Lokesh
Author Wang, Joseph
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Collected From figshare
Hosted By figshare
Publication Date 2016-03-01
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Language English
Resource Type Other literature type
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=r37980778c78::9feffbfc59c264dde3b3fdf54b97ba5b
Author jsonws_user
Last Updated 22 December 2020, 13:39 (CET)
Created 22 December 2020, 13:39 (CET)