Characterization of Dengue Virus Type 2: New Insights on the 2010 Brazilian Epidemic

Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State. Partial envelope viral genes were sequenced from eighteen patients with dengue fever during the 2010 epidemic. Phylogenetic analysis showed this strain belongs to the American/Asian genotype and was closely related to the virus that circulated in Rio de Janeiro in 2007 and 2008. The phylogeny also showed no clustering by clinical presentation, suggesting that the disease severity could not be explained by distinct variants or genotypes. The time of the most recent common ancestor of American/Asian genotype and the São Paulo and Rio de Janeiro (SP/RJ) monophyletic cluster was estimated to be around 40 and 10 years, respectively. Since this virus was first identified in Brazil in 2007, we suggest that it was already circulating in the country before causing the first documented outbreak. This is the first description of the 2010 outbreak in the State of São Paulo, Brazil, and should contribute to efforts to control and monitor the spread of DENVs in endemic areas.

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PID https://www.doi.org/10.1371/journal.pone.0011811
URL https://figshare.com/articles/dataset/Characterization_of_Dengue_Virus_Type_2_New_Insights_on_the_2010_Brazilian_Epidemic/142462
URL https://figshare.com/articles/Characterization_of_Dengue_Virus_Type_2_New_Insights_on_the_2010_Brazilian_Epidemic/142462
URL http://dx.doi.org/10.1371/journal.pone.0011811
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Author Malta Romano, Camila
Author Manso de Matos, Andréia
Author Stanislau A. Araújo, Evaldo
Author Santos Villas-Boas, Lucy
Author Cardoso da Silva, Wanessa
Author M. N. P. F. Oliveira, Olímpia
Author I. Carvalho, Karina
Author Carolina Mamana de Souza, Ana
Author L. Rodrigues, Celia
Author Eduardo Levi, José
Author G. Kallas, Esper
Author Sergio Pannuti, Claudio
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Collected From figshare
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Publication Date 2016-01-01
Publisher Figshare
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Source https://science-innovation-policy.openaire.eu/search/dataset?datasetId=r37980778c78::6de77e36d78bce8e4f4ec530e9da8725
Author jsonws_user
Last Updated 13 January 2021, 15:01 (CET)
Created 13 January 2021, 15:01 (CET)