r37980778c78--6c7815ee310aa3e71cae6508de8b29ba

Flavonoids are plant secondary metabolites often used as nutraceutical supplements, but a growing number of unnatural flavonoids are being investigated as therapeutic agents. Cultures of Saccharomyces cerevisiae expressing recombinant flavonoid enzymes, including 4-coumaroyl:CoA ligase (4CL), chalcone synthase (CHS), chalcone isomerase (CHI), and flavanone 3β-hydroxylase (FHT), produced novel flavanones and dihydroflavonols when fed with a number of aromatic acrylic acids. The flavonoid network also exhibited broad substrate specificity by converting muconic acid into a unique polypropanoid.

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PID https://www.doi.org/10.1021/ol0703736.s001
URL https://figshare.com/articles/journal_contribution/Combinatorial_Mutasynthesis_of_Flavonoid_Analogues_from_Acrylic_Acids_in_Microorganisms/3008452
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Collected From figshare
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Publication Date 2016-02-29
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=r37980778c78::6c7815ee310aa3e71cae6508de8b29ba
Author jsonws_user
Last Updated 25 December 2020, 16:51 (CET)
Created 25 December 2020, 16:51 (CET)