The article deals with the analysis of the problems related to unemployment in the Moravian and Silesian Region in the Czech Republic. We have analysed the problems by means of age and education structure of population and thereafter by means of the sector structure. The analysis results provide evidence that the sector structure as well as the age structure of population in the Region shows similar tendencies like in the Czech Republic. The education structure of the Region’s population reflects the previous orientation of the Region to mining and raw material exploitation and carries along a number of problems related to the structural unemployment as a result of the Region's restructuring. The unemployment rate in the Region exceeds the national average and the individual areas of the Region achieve double amounts. In addition, the analysis indicates that the wage level in the Region when compared to the CZ develops similarly in the individual sectors; the differences tend to deepen, however. The benefits of solution of these problems may be seen in the increasing interest of foreign investors in the Region, namely in the area of modern manufacturing industry and sophisticated sectors.