Tissue-specific regulation of CYP3A by hydrolysable tannins in male pigs
  1. Little is known about the activities and regulation of cytochrome P4503A (CYP3A) enzymes in porcine colon in response to specific feeding components. 2. We added hydrolyzable tannins to the diet of fattening boars and studied its effect on the expression of hepatic and intestinal CYP3A. 3. In total, 51 Landrace × Large White boars were assigned to the following treatment groups: control (without the addition of hydrolysable tannins), T1 (diet-containing 1% hydrolysable tannin extract), T2 (diet-containing 2% hydrolysable tannin extract) and T3 (diet-containing 3% hydrolysable tannin extract). CYP3A expression and activity were measured in microsomes prepared from liver and colon tissue. 4. CYP3A protein expression and activity were increased in the colon of pigs fed 2% and 3% tannins, while no changes were observed with lower tannin concentrations, or in the liver of any treatment groups. Also, it was demonstrated that colon mucosa possess CYP3A activity similar to that measured in the liver. 5. The present results provide the first evidence that tannin supplementation can modulate CYP3A in porcine colon mucosa in vivo. The physiological significance of this finding for the health status of the individual animal needs further investigation.
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PID https://www.doi.org/10.3109/00498254.2015.1099081
PID https://www.doi.org/10.6084/m9.figshare.1591494.v1
PID https://www.doi.org/10.6084/m9.figshare.1591494
URL http://dx.doi.org/10.6084/m9.figshare.1591494.v1
URL https://core.ac.uk/display/150090041
URL http://dx.doi.org/10.6084/m9.figshare.1591494
URL https://www.ncbi.nlm.nih.gov/pubmed/26526407
URL https://www.tandfonline.com/doi/ref/10.3109/00498254.2015.1099081
URL http://www.tandfonline.com/doi/full/10.3109/00498254.2015.1099081
URL http://dx.doi.org/10.3109/00498254.2015.1099081
URL http://europepmc.org/abstract/MED/26526407
URL https://pure.au.dk/portal/da/publications/tissuespecific-regulation-of-cyp3a-by-hydrolysable-tannins-in-male-pigs(36764032-fd12-48f3-93c7-b359147a3d1a).html
URL http://www.tandfonline.com/doi/pdf/10.3109/00498254.2015.1099081
URL https://academic.microsoft.com/#/detail/2169981686
URL https://doi.org/10.3109/00498254.2015.1099081
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Access Right Open Access
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Author Martin Krøyer Rasmussen, 0000-0002-1889-2874
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Collected From ORCID; Datacite; figshare; Crossref; PURE Aarhus University; Microsoft Academic Graph
Hosted By figshare; PURE Aarhus University; Xenobiotica
Journal Xenobiotica, 46, null
Publication Date 2015-11-02
Publisher Informa UK Limited
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Resource Type Other literature type; Article
keyword keywords.Health, Toxicology and Mutagenesis
keyword FOS: Biological sciences
keyword FOS: Chemical sciences
keyword FOS: Health sciences
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::fe42afe22930fb560e29419eac8519c1
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Last Updated 24 December 2020, 20:51 (CET)
Created 24 December 2020, 20:51 (CET)