Antimutagenic activity of flavonoids from Sozuku

Pinocembrin (1) and cardamonin (2) from Sozuku showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen furylfuramide. Compounds 1 and 2 suppressed 52% and 36% of SOS-inducing activity at a concentration of 0.20 μmol/mL. The ID50 value of 1 was 0.18 μmol/mL. These compounds showed the suppression of 2-amino-3,4-dimethylimidazo-[4,5-f]quinolone (MeIQ) and UV irradiation-induced SOS response. Pinostrobin (3) and 5,7-dimethoxyflavanone (4), methyl ethers of 1, showed similar activity to 1 against MeIQ-induced SOS response, but that of furylfuramide and UV irradiation were decreased. On the other hand, compounds 1–4 did not show the suppression of activated MeIQ-induced SOS response. Furthermore, compounds 1–4 showed potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains.

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PID https://www.doi.org/10.1080/14786419.2017.1408104
PID https://www.doi.org/10.6084/m9.figshare.5643973.v1
PID https://www.doi.org/10.6084/m9.figshare.5643973
URL https://www.ncbi.nlm.nih.gov/pubmed/29183163
URL https://core.ac.uk/display/149342592
URL http://dx.doi.org/10.6084/m9.figshare.5643973.v1
URL http://dx.doi.org/10.6084/m9.figshare.5643973
URL http://dx.doi.org/10.1080/14786419.2017.1408104
URL https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1408104
URL https://www.tandfonline.com/doi/pdf/10.1080/14786419.2017.1408104
URL https://academic.microsoft.com/#/detail/2770864140
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Author Okuno, Yoshiharu
Author Marumoto, Shinsuke
Author Miyazawa, Mitsuo
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Collected From Datacite; figshare; Crossref; Microsoft Academic Graph
Hosted By Natural Product Research; figshare
Journal Natural Product Research, 33, null
Publication Date 2017-11-28
Publisher Informa UK Limited
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Resource Type Other literature type; Article
keyword FOS: Biological sciences
keyword FOS: Earth and related environmental sciences
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::f7035cc3f91bcee1d6425128b8fa6b12
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Last Updated 26 December 2020, 20:26 (CET)
Created 26 December 2020, 20:26 (CET)