"What is the structural chemistry of the living organism at its temperature and pressure?"

The three probes of the structure of matter (X-rays, neutrons and electrons) in biology have complementary properties and strengths. For the study of combined states of order and disorder, NMR crystallography is also applicable. Overall, to understand a biological system, the requirements are physiologically relevant results. Reporting of protein crystal structures, and their associated database entries, could usefully indicate how close to the biological situation they are.

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PID https://www.doi.org/10.5281/zenodo.3565338
PID https://www.doi.org/10.1107/s2059798320000546
PID https://www.doi.org/10.5281/zenodo.3565339
PID pmc:PMC7008516
PID pmid:32038039
URL https://zenodo.org/record/3565339
URL http://dx.doi.org/10.5281/zenodo.3565339
URL https://figshare.com/articles/_What_is_the_structural_chemistry_of_the_living_organism_at_its_temperature_and_pressure_/11441175
URL http://dx.doi.org/10.1107/s2059798320000546
URL http://dx.doi.org/10.5281/zenodo.3565338
URL https://academic.microsoft.com/#/detail/3004773293
URL http://europepmc.org/articles/PMC7008516
URL http://scripts.iucr.org/cgi-bin/paper?nw5093
URL https://journals.iucr.org/d/issues/2020/02/00/nw5093/nw5093.pdf
URL http://journals.iucr.org/d/issues/2020/02/00/nw5093/nw5093.pdf
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Access Right Open Access
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Author Helliwell, John R., 0000-0002-0520-7540
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Collected From PubMed Central; ORCID; Datacite; UnpayWall; figshare; Crossref; Microsoft Academic Graph; FigShare
Hosted By Zenodo; Europe PubMed Central; figshare; FigShare; Acta Crystallographica Section D Structural Biology
Publication Date 2019-12-06
Publisher Zenodo
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Description The three probes of the structure of matter (X-rays, neutrons and electrons) in biology have complementary properties and strengths. The balance between these three probes within their strengths and weaknesses is perceived to change, even dramatically so at times. For the study of combined states of order and disorder, NMR crystallography is also applicable. Of course, to understand biological systems the required perspectives are surely physiologically relevant temperatures and relevant chemical conditions, as well as a minimal perturbation owing to the needs of the probe itself. These remain very tough challenges because, for example, cryoEM by its very nature will never be performed at room temperature, crystallization often requires nonphysiological chemical conditions, and X-rays and electrons cause beam damage. However, integrated structural biology techniques and functional assays provide a package towards physiological relevance of any given study. Reporting of protein crystal structures, and their associated database entries, could usefully indicate how close to the biological situation they are, as discussed in detail in this feature article.
Language UNKNOWN
Resource Type Other literature type; Conference object; Article
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::e4681ba3dfe3c352284352a3b0802bf9
Author jsonws_user
Last Updated 26 December 2020, 10:53 (CET)
Created 26 December 2020, 10:53 (CET)