Context-Dependent Photodimerization in Isolated Thymine−Thymine Steps in DNA

The effect of 280 nm irradiation on a family of synthetic DNA hairpins possessing an alkane linker connecting a six-base pair stem having a single T−T step located at different positions within the hairpin has been investigated. A single adduct assigned to the product of 2+2 dimerization is obtained except in the case of a T−T step located adjacent to the linker, in which case both 2+2 and 6−4 adducts are obtained. The efficiency of dimerization is similar for three hairpins having a T−T step located within the duplex interior. Lower efficiency is observed for a T−T step located at the open end of the hairpin and in T overhangs, whereas higher efficiency is observed for the T−T step adjacent to the linker and in a single T bulge. The context-dependence of dimerization efficiency is discussed.

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PID https://www.doi.org/10.1021/ja804950j
PID https://www.doi.org/10.1021/ja804950j.s001
URL https://pubs.acs.org/doi/pdf/10.1021/ja804950j
URL https://www.ncbi.nlm.nih.gov/pubmed/18702486
URL https://core.ac.uk/display/153082091
URL http://europepmc.org/abstract/MED/18702486
URL https://www.scholars.northwestern.edu/en/publications/context-dependent-photodimerization-in-isolated-thymine-thymine-s
URL https://pubs.acs.org/doi/10.1021/ja804950j
URL https://figshare.com/articles/journal_contribution/Context_Dependent_Photodimerization_in_Isolated_Thymine_Thymine_Steps_in_DNA/2914831
URL http://dx.doi.org/10.1021/ja804950j
URL http://pubs.acs.org/doi/abs/10.1021/ja804950j
URL https://academic.microsoft.com/#/detail/1978547072
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Access Right Open Access
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Author Hariharan, Mahesh
Author Lewis, Frederick D.
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Collected From figshare; Crossref; Microsoft Academic Graph
Hosted By Journal of the American Chemical Society; figshare
Journal Journal of the American Chemical Society, 130, null
Publication Date 2008-09-10
Publisher American Chemical Society (ACS)
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Resource Type Other literature type; Article
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::e3ee5be597abced730ee430c63d66ff4
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Last Updated 22 December 2020, 18:39 (CET)
Created 22 December 2020, 18:39 (CET)