Gli1 regulates stemness characteristics in gastric adenocarcinoma

Abstract Background Glioma-associated oncogene homolog 1 (Gli1), affects the progression and the stemness characteristics of malignant carcinoma. The aim of the present study was to identify the relation between Glioma-associated oncogene homolog 1 (Gli1) and stemness and determine its clinical significance in gastric adenocarcinoma (GA). We investigated Gli1 expression and its correlation with other stemness-associated proteins in 169 GA samples and 5 GA cell lines. Methods To elucidate the role of Gli1 in the clinicopathological significance and stemness of GA, tissues samples from 169 GA patients were collected for immunohistochemistry (IHC). Additionally, MKN74, MKN28, NCI-N87, SNU638, AGS cells were collected for western blotting, MKN28 cells were collected for spheroid formation assay. Results Results showed that Gli1 expression was closely related to tumor grade, primary tumor (pT) stage, distant metastasis, clinical stage, gross type, microvessel density, and shorter overall survival (OS). Cox regress...

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PID https://www.doi.org/10.6084/m9.figshare.c.4985303.v1
PID https://www.doi.org/10.6084/m9.figshare.c.4985303
URL https://dx.doi.org/10.6084/m9.figshare.c.4985303
URL https://dx.doi.org/10.6084/m9.figshare.c.4985303.v1
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Author Wenbo Qi
Author Zhaoting Yang
Author Feng, Ying
Author Haoyue Li
Author Che, Nan
Author Liu, Lan
Author Yanhua Xuan
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Publication Date 2020-05-20
Publisher figshare
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Source https://science-innovation-policy.openaire.eu/search/dataset?datasetId=dedup_wf_001::e19a4ba4a455db1c8320eb55c20617a5
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Last Updated 15 December 2020, 19:16 (CET)
Created 15 December 2020, 19:16 (CET)